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Sapropterin CAS# 62989-33-7 / 69056-38-8 沙丙蝶呤
Sapropterin, also known as Tetrahydrobiopterin (BH4, THB, trade name Kuvan) or sapropterin (INN) is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used ...
Lyudnikova, T. A.; Dashina, O. A.; Telegina, T. A.; Kritsky, M. S. Investigation of the photochemical properties of biopterin and its reduced forms. Applied Biochemistry and Microbiology. Volume 45. Issue 1. Pages 104-109. 2009.
Imipenem CAS# 64221-86-9 亚胺培南
Imipenem is as emisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains...
Reference: Qin, Yun; Bai, Zhiquan; Liu, Xicheng; Wu, Jianjun; Tang, Hong. A process for preparing imipenem and its intermediates. Assignee Chongqing Tiandi Pharmaceutical Co., Ltd., Peop. Rep. China. CN 108623598. (2018).
Asenapine CAS# 65576-45-6 阿塞那平
Asenapine, also known as Org 5222 and HSDB 8061, shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5...
Synthesis of asenapine; Zhang, Xiao-ying; Zheng, Guo-jun Huaxue Shiji Volume 33 Issue 12 Pages 1135-1137 Journal 2011
Dienogest CAS# 65928-58-7 地诺孕素
Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a resu...
Liang, Yong; Chen, Bo; Wang, Shaojie. Synthesis of dienogest. Shenyang Yaoke Daxue Xuebao. Volume 28. Issue 10. Pages 788-790. Journal. (2011).
Motixafortide CAS# 664334-36-5
Motixafortide, also known as BL-8040, BKT140 and TF 14016, is an orally bioavailable inhibitor of CXC Chemokine Receptor 4 (CXCR4) with potential antineoplastic activity. CXCR4 antagonist BKT140 selec...
PET of tumor CXCR4 expression with 4-18F-T140By: Jacobson, Orit; et alJournal of Nuclear Medicine (2010), 51(11), 1796-1804
Acoltremon CAS# 68489-09-8 凉味剂WS-12
Acoltremon (WS-12) is a potent and selective TRPM8 agonist, demonstrating an EC₅₀ of approximately 39–193 nM, which is significantly more potent than menthol (EC₅₀ ≈ 196 µM) . In preclinical studies, ...
Preparation of key intermediate menthyl formic acid of WS series cooling agentAssignee: Jiangsu Hongbang Chemical Technology Co., Ltd.Inventors: Du, Dengtao; et alChinaPatent#CN117945886
Triclabendazole CAS# 68786-66-3 三氯苯达唑
Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals ...
Iddon, Brian; Kutschy, Peter; Robinson, Andrew G.; Suschitzky, Hans; Kramer, Walter; Neugebauer, Franz A. 2H-Benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), Issue 22, Pages 3129-34, 1992.
Ceftolozane CAS# 689293-68-3 5-氨基-2-{(6R,7R)-7-(2Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(1-羧基-1-甲基氧基)亚胺乙酰胺-2-羧基-8-氧基-5-硫胺-1-氮基环4.2.0oct-2-烯-3-甲基甲基}-4-{(2-氨基乙基)氨基酰胺}-1-甲基-1H-吡氮唑-2-铀
Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria....
Fischer, Michael; Felzmann, Wolfgang. Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-ACA). Assignee Sandoz AG, Switz. WO 2017042188. (2017).
Rifamycin CAS# 6998-60-3 利福霉素
Rifamycin is a natural antibiotic which inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis, thereby blocking RNA-polymerase transcription initiation.
Reference: Zhao, Deming; Li, Zhifa; Zhang, Yan; Li, Zhuo; Chen, Jianhua; Zhang, Yanying; Hu, Yahui. Preparation method of rifamycin S. Assignee Shenyang Antibiotics Factory, Peop. Rep. China. CN 105237548. (2016).
Trifluridine CAS# 70-00-8 曲氟尿苷
Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into Gl...
Reference: Fernandez-Lucas, Jesus; Fresco-Taboada, Alba; Acebal, Carmen; Mata, Isabel; Arroyo, Miguel. Applied Microbiology and Biotechnology. Enzymatic synthesis of nucleoside analogues using immobilized 2'-deoxyribosyltransferase from Lactobacillus reuteriVolume. 91. Issue 2. Pages 317-327. Journal; Online Computer File (2011)
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