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Avatrombopag CAS# 570406-98-3 马来酸阿伐曲波帕
Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryo...
Reference: Miao, Dezu; Hu, Qingwen; Cong, Chao; Cao, Yan; Yu, Zhibo; Wang, Hongguang. Preparation method of platelet increasing agent Avatrombopag. Assignee Reyoung Pharmaceutical Co., Ltd., Peop. Rep. China. CN 107383000. (2017).
Palbociclib CAS# 571190-30-2 帕布昔利布
Palbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4...
Reference: Toogood PL, Harvey PJ, Repine JT, Sheehan DJ, VanderWel SN, Zhou H, Keller PR, McNamara DJ, Sherry D, Zhu T, Brodfuehrer J, Choi C, Barvian MR, Fry DW. Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem. 2005 Apr 7;48(7):2388-406. PubMed PMID: 15801831.
Tetrabenazine CAS# 58-46-8 丁苯那嗪
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorder. On August 15, 2008 the U.S. Food and Drug Administration (FDA) approved the use of tetrabenazine to treat chore...
Son, Young Wook; Kwon, Tae Hui; Lee, Jae Kyun; Pae, Ae Nim; Lee, Jae Yeol; Cho, Yong Seo; Min, Sun-Joon. A concise synthesis of tetrabenazine: An intramolecular aza-Prins-type cyclization via oxidative C-H activation. Organic Letters. Volume 13. Issue 24. Pages 6500-6503. 2011.
Lactitol CAS# 585-86-4 乳糖醇
Lactitol is a synthetic disaccharide polyol derived from lactose, used primarily as an osmotic laxative and low-calorie sweetener. In vitro studies demonstrate that it resists hydrolysis by human smal...
Continuous Hydrogenation of Maltose over Raney Ni in a Trickle-Bed ReactorBy: Fan, Haoan; et alIndustrial & Engineering Chemistry Research (2023), 62(38), 15395-15405
Tafamidis CAS# 594839-88-0 2-(3,5-二氯苯基)-6-苯并恶唑甲酸
Tafamidis, Tafamidis, also known as Fx-1006 or PF-06291826, is a drug for the amelioration of transthyretin-related hereditary amyloidosis (also familial amyloid polyneuropathy, or FAP), a rare but de...
Simoes, Carlos J. V.; Almeida, Zaida L.; Costa, Dora; Jesus, Catarina S. H.; Cardoso, Ana L.; Almeida, Maria R.; Saraiva, Maria J.; Pinho e Melo, Teresa M. V. D.; Brito, Rui M. M.
Fexinidazole CAS# 59729-37-2 非昔硝唑
Fexinidazole, also known as Hoe-239, antiparasitic agent potentially for the treatment of trypanosomiasis and leishmaniasis. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomon...
By: Samant, Bhupesh S.; et alBioorganic & Medicinal Chemistry Letters (2011), 21(3), 1015-1018
Binimetinib CAS# 606143-89-9 贝美替尼
Binimetinib, also known as MEK162 (ARRY-162), is an oral, highly selective MEK inhibitor. In preclinical studies, MEK162 showed significant antitumor activities in cell lines and animal models. MEK162...
Anon. Process for the preparation of 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benz[d]imidazole-6-carboxylic acid. IP.com Journal. Volume 15. Issue 12B. Pages 1pp.Journal; Patent. (2015).
Vigabatrin CAS# 60643-86-9 氨己烯酸
Vigabatrin, also known as gamma-vinyl-GABA, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of GABA transaminase (GABA-T). It is a s...
Deleris, G.; Dunogues, J.; Gadras, A. Direct regiospecific allylic amination via silicon induced pericyclic reactions. A novel synthesis of gamma vinyl GABA. Tetrahedron. Volume 44. Issue 13. Pages 4243-58. 1988.
Apremilast CAS# 608141-41-9 阿普斯特
Apremilast, also known as CC-10004, is a thalidomide analog and is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast specifically inhibits PDE4 and inhibits sponta...
Syu, Jin-Fong; Gopula, Balraj; Jian, Jia-Hong; Li, Wei-Sian; Kuo, Ting-Shen; Wu, Ping-Yu; Henschke, Julian P.; Hsieh, Meng-Chi; Tsai, Ming-Kang; Wu, Hsyueh-Liang. Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast. Organic Letters. Volume 21. Issue 12. Pages 4614-4618. Journal; Online Computer File. (2019).
Triheptanoin CAS# 620-67-7 三庚酸甘油酯
Triheptanoin, a medium-chain triglyceride composed of three heptanoic acid chains, has demonstrated significant preclinical bioactivity as an anaplerotic substrate capable of replenishing tricarboxyli...
Catalyst-controlled polycondensation of glycerol with diacyl chlorides: linear polyesters from a trifunctional monomerBy: Slavko, Ekaterina; et alChemical Science (2017), 8(10), 7106-7111
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