Triheptanoin CAS# 620-67-7 三庚酸甘油酯

Triheptanoin, a medium-chain triglyceride composed of three heptanoic acid chains, has demonstrated significant preclinical bioactivity as an anaplerotic substrate capable of replenishing tricarboxylic acid (TCA) cycle intermediates and improving cellular energy metabolism in models of metabolic and neurological disorders. In rodent models of long-chain fatty acid oxidation disorders (LC-FAOD), triheptanoin supplementation increased hepatic and muscular acetyl-CoA and propionyl-CoA levels, enhanced ATP production, and reduced accumulation of toxic long-chain acylcarnitines. In a mouse model of glucose transporter type 1 deficiency syndrome (Glut1DS), triheptanoin elevated brain TCA cycle intermediates, improved locomotor activity, and reduced seizure frequency. In amyotrophic lateral sclerosis (ALS) mouse models, it preserved motor neuron integrity and delayed disease progression, correlated with increased spinal cord energy metabolites.