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Stiripentol (marketed as Diacomit by Laboratoires Biocodex) is an anticonvulsant drug used in the treatment of epilepsy. It is approved for the treatment of Dravet syndrome, an epilepsy syndrome. Stir...
Hu, Aixi; Wu, Zhilin; Ye, Jiao. (Assignee Hunan University, Peop. Rep. China). Preparation method of stiripentol. CN 102690252. (2012).
Givinostat (ITF-2357) is a hydroxamic acid-based histone deacetylase (HDAC) inhibitor with potent anti-inflammatory and antineoplastic activity. It selectively inhibits class I and II HDACs, leading t...
Patent#: WO2020178776
Lurbinectedin (PM01183) is a synthetic tetrahydroisoquinoline alkaloid related to trabectedin that binds covalently to the minor groove of DNA, inhibiting oncogenic transcription and inducing DNA doub...
He WM, Zhang ZG, Ma DW. A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin. Agnew. Chem. Int. Ed. 2019, 58(12):3972-3975.
Odevixibat (A4250) is a potent, selective, and minimally absorbed inhibitor of the ileal bile acid transporter (IBAT, also known as ASBT or SLC10A2), designed to reduce enterohepatic bile acid recircu...
Patent#: WO2024184924
Apixaban, also known as BMS-56224701, is an anticoagulant for the treatment of venous thromboembolic events. Apixaban is a direct factor Xa inhibitor. Apixaban was approved in 2012. Apixaban is indica...
Sun, Xiaoqing; Hong, Zexin; Liu, Moyi; Guo, Su; Yang, Di; Wang, Yong; Lan, Tian; Gao, Linyu; Qi, Hongxia; Gong, Ping; Liu, Yajing. Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity. Bioorganic & Medicinal Chemistry. Volume 25. Issue 10. Pages 2800-2810. Journal; Online Computer File. (2017).
Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. It has been a...
Process for preparation of aminopyridine from methylpyridine; Zhang, Sheng; Zhang, Kuanyu; Jin, Wenyi; Li, Jing Assignee Anhui Xingyu Chemical Co., Ltd., Peop. Rep. China 2017; Patent Information; Aug 04, 2017; CN 107011255 A
Brexanolone, also known as 3a5a-Allopregnanolone; Allotetrahydroprogesterone and Allopregnanolone, is a GABA(A) receptor modulator potentially for the treatment of epilepsy and depression. Brexanolone...
MacNevin, Christopher J.; Atif, Fahim; Sayeed, Iqbal; Stein, Donald G.; Liotta, Dennis C. Development and Screening of Water-Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury. Journal of Medicinal Chemistry. Volume 52. Issue 19. Pages 6012-6023. Journal. (2009).
Raltegravir, also known as MK-0518, is an antiretroviral drug used to treat HIV infection. Raltegravir is a human immunodeficiency virus (HIV) integrase strand transfer inhibitor (HIV-1 INSTI) with HI...
Patil, Gulabrao D.; Kshirsagar, Siddheshwar W.; Shinde, Shivnath B.; Patil, Pankaj S.; Deshpande, Mangesh S.; Chaudhari, Ashok T.; Sonawane, Swapnil P.; Maikap, Golak C.; Gurjar, Mukund K. Identification, Synthesis, and Strategy For Minimization of Potential Impurities Observed In Raltegravir Potassium Drug Substance. Organic Process Research & Development. Volume 16. Issue 8. Pages 1422-1429. 2012.
Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian evergreen tree of the Apocynaceae family. Ell...
Dilek, Omer; Patir, Suleyman; Tilki, Tahir; Erturk, Erkan. Total Synthesis of Olivacine and Ellipticine via a Lactone Ring-Opening and Aromatization Cascade. Journal of Organic Chemistry. Volume 84. Issue 12. Pages 7901-7916. Journal; Online Computer File. (2019).
Mavorixafor, also known as AMD11070, AMD070, X4P-001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 m...
Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine ReceptorBy: Dekkers, Sebastian; et alJournal of Medicinal Chemistry (2023), 66(7), 5208-5222
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