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Tenofovir alafenamide CAS# 379270-37-8 替诺福韦艾拉酚胺
Tenofovir alafenamide, also known as TAF and GS-7340, is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of tenofovir. By blocking reverse transcriptase, TAF prevent HIV from ...
Reference: Zhang, Wei; Liao, Wensheng. Method for preparing tenofovir alafenamide Zhang, Wei; Liao, Wensheng. CN 108623632. (Shanghai Steppharm Co., Ltd., Peop. Rep. China)
Melphalan Flufenamide CAS# 380449-51-4 美法仑氟灭酰胺
Melphalan flufenamide (melflufen, J1, or L-PAM-2) is a lipophilic peptide–drug conjugate that delivers melphalan intracellularly via aminopeptidase activity. In preclinical studies, it demonstrated po...
Structure-activity relationship for alkylating dipeptide nitrogen mustard derivativesBy: Gullbo, Joachim; et alOncology Research (2003), 14(3), 113-132
Bosutinib CAS# 380843-75-4 伯舒替尼
Bosutinib, also known as SKI-606, is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib...
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Sosa, Ana Carolina Barrios; Golas, Jennifer M.; Boschelli, Frank. 7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases. Journal of Medicinal Chemistry. Volume 47. Issue 7. Pages 1599-1601. Journal. (2004).
Omadacycline CAS# 389139-89-3
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired met...
Reference: Chung, John Y. L.; Hartner, Frederick W.; Cvetovich, Raymond J. Synthesis development of an aminomethylcycline antibiotic via an electronically tuned acyliminium Friedel-Crafts reaction. Tetrahedron Letters. Volume 49. Issue 42. Pages 6095-6100. Journal. (2008).
Mirdametinib CAS# 391210-10-9 N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺
Mirdametinib, also known as PD-0325901, is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplas...
Optically activated MEK1/2 inhibitors (Opti-MEKi) as potential antimelanoma agentsBy: Hao, Chenzhou; et alEuropean Journal of Medicinal Chemistry (2023), 251, 115236
Boceprevir CAS# 394730-60-0 波普瑞韦
Boceprevir (INN, trade name Victrelis) is a protease inhibitor used as a treatment for hepatitis C genotype 1. It binds to HCV nonstructural 3 NS3 (HCV) active site. It was being developed by Schering...
Venkatraman, Srikanth; Bogen, Stephane L.; Arasappan, Ashok; Bennett, Frank; Chen, Kevin; Jao, Edwin; Liu, Yi-Tsung; Lovey, Raymond; Hendrata, Siska; Huang, Yuhua; Pan, Weidong; Parekh, Tejal; Pinto, Patrick; Popov, Veljko; Pike, Russel; Ruan, Sumei; Santhanam, Bama; Vibulbhan, Bancha; Wu, Wanli; Yang, Weiying; Kong, Jianshe; Liang, Xiang; Wong, Jesse; Liu, Rong; Butkiewicz, Nancy; Chase, Robert; Hart, Andrea; Agrawal, Sony; Ingravallo, Paul; Pichardo, John; Kong, Rong; Baroudy, Bahige; Malcolm, Bruce; Guo, Zhuyan; Prongay, Andrew; Madison, Vincent; Broske, Lisa; Cui, Xiaoming; Cheng, Kuo-Chi; Hsieh, Tony Y.; Brisson, Jean-Marc; Prelusky, Danial; Korfmacher, Walter; White, Ronald; Bogdanowich-Knipp, Susan; Pavlovsky, Anastasia; Bradley, Prudence; Saksena, Anil K.; Ganguly, Ashit; Piwinski, John; Girijavallabhan, Viyyoor; Njoroge, F. George. Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection. Journal of Medicinal Chemistry. Volume 49. Issue 20. Pages 6074-6086. Journal. (2006).
Telaprevir CAS# 402957-28-2 特拉匹伟
Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a ...
Moni, Lisa; Banfi, Luca; Basso, Andrea; Carcone, Luca; Rasparini, Marcello; Riva, Renata. Ugi and Passerini Reactions of Biocatalytically Derived Chiral Aldehydes: Application to the Synthesis of Bicyclic Pyrrolidines and of Antiviral Agent Telaprevir. Journal of Organic Chemistry. Volume 80. Issue 7. Pages 3411-3428. Journal; Online Computer File. (2015).
Panobinostat CAS# 404950-80-7 帕比司他
Panobinostat, also known as NVP LBH-589 or LBH-589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducin...
Reference: Chen, Shanwen & Zhang, Peiming & Chen, Huali & Yu, Yu & Gan, Zongjie. (2018). An Improved and Efficient Synthesis of Panobinostat. Journal of Chemical Research. 42. 471-473. 10.3184/174751918X15357309308931.
Palovarotene CAS# 410528-02-8 4-[(1E)-2-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(1H-吡唑-1-基甲基)-2-萘基]乙烯基]苯甲酸
Palovarotene, a selective retinoic acid receptor gamma (RARγ) agonist, demonstrates potent bioactivity in preclinical models by targeting the pathogenic signaling in fibrodysplasia ossificans progress...
An anthranilamide-substituted borane [H-B(aam)]: its stability and application to iridium-catalyzed stereoselective hydroboration of alkynesBy: Yoshida, Hiroto; et alChemical Communications (Cambridge, United Kingdom) (2019), 55(38), 5420-5422
Uridine Triacetate CAS# 4105-38-8 2,3,5-三乙酰尿苷
Uridine triacetate is a drug used in the treatment of hereditary orotic aciduria and to treat patients following an overdose of chemotherapy drugs 5-fluorouracil or capecitabine, or in patients exhibi...
Reference: Zhou, X. X.; Welch, C. J.; Chattopadhyaya, J. Pyridyl groups for protection of the imide functions of uridine and guanosine. Exploration of their displacement reactions for site-specific modifications of uracil and guanine bases. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry. Volume B40. Issue 10. Pages 806-16. Journal. (1986).
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