Telaprevir CAS# 402957-28-2 特拉匹伟
Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors. Specifically, telaprevir inhibits the hepatitis C viral enzyme NS3.4A serine protease. Telaprevir is only indicated for use against hepatitis C genotype 1 viral infections and has not been proven to have an effect on or being safe when used for other genotypes of the virus. The standard therapy of pegylated interferon and ribavirin is less effective on genotype 1.
📌 参考资料/链接:
Moni, Lisa; Banfi, Luca; Basso, Andrea; Carcone, Luca; Rasparini, Marcello; Riva, Renata. Ugi and Passerini Reactions of Biocatalytically Derived Chiral Aldehydes: Application to the Synthesis of Bicyclic Pyrrolidines and of Antiviral Agent Telaprevir. Journal of Organic Chemistry. Volume 80. Issue 7. Pages 3411-3428. Journal; Online Computer File. (2015).
📄 详细内容
CAS No. 402957-28-2 特拉匹伟Telaprevir synthetic routes

Moni, Lisa; Banfi, Luca; Basso, Andrea; Carcone, Luca; Rasparini, Marcello; Riva, Renata. Ugi and Passerini Reactions of Biocatalytically Derived Chiral Aldehydes: Application to the Synthesis of Bicyclic Pyrrolidines and of Antiviral Agent Telaprevir. Journal of Organic Chemistry. Volume 80. Issue 7. Pages 3411-3428. Journal; Online Computer File. (2015).
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