Uridine Triacetate CAS# 4105-38-8 2,3,5-三乙酰尿苷
Uridine triacetate is a drug used in the treatment of hereditary orotic aciduria and to treat patients following an overdose of chemotherapy drugs 5-fluorouracil or capecitabine, or in patients exhibiting early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of 5-fluorouracil or capecitabine administration. Uridine triacetate was granted breakthrough therapy designation by FDA in 2015. Uridine triacetate is a prodrug of uridine.
📌 参考资料/链接:
Reference: Zhou, X. X.; Welch, C. J.; Chattopadhyaya, J. Pyridyl groups for protection of the imide functions of uridine and guanosine. Exploration of their displacement reactions for site-specific modifications of uracil and guanine bases. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry. Volume B40. Issue 10. Pages 806-16. Journal. (1986).
📄 详细内容
CAS No. 4105-38-8 2,3,5-三乙酰尿苷Uridine Triacetate synthetic routes

Zhou, X. X.; Welch, C. J.; Chattopadhyaya, J. Pyridyl groups for protection of the imide functions of uridine and guanosine. Exploration of their displacement reactions for site-specific modifications of uracil and guanine bases. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry. Volume B40. Issue 10. Pages 806-16. Journal. (1986).
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