CAS: 4105-38-8; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)Tetrahydrofuran-3,4-Diyl Diacetate

相似化合物

2140-76-3 58-96-8 26287-69-4

上下游产品

CAS号108-24-7 乙酸酐 | CAS号58-96-8 尿苷 | CAS号55003-25-3 (2R,3R,4R,5R)-2... | CAS号66-22-8 尿嘧啶 | CAS号13035-61-5 四乙酰核糖 | CAS号116393-66-9 N3-benzyloxymet... | CAS号67-56-1 甲醇 | CAS号3736-77-4 2,2'-脱水尿苷 | CAS号58-96-8 尿苷 | CAS号65-46-3 胞嘧啶核苷 | CAS号20724-73-6 2'-C-甲基胞嘧啶核苷 | CAS号957-75-5 5-溴尿苷 | CAS号2341-22-2 5-氟胞苷 | CAS号65-47-4 5'-三磷酸胞苷 | CAS号69075-42-9 5-乙炔啶(5-EU) | CAS号13007-43-7 N4,N4-Dimethylc... | CAS号1024-99-3 5-碘尿苷

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-Hydroxymethyl-Tetrahydro-Furan-2-yl)-4-(2-Oxo-2H-Pyridin-1-yl)-1H-Pyrimidin-2-One置于吡啶,四甲基胍,4-硝基苯甲醛肟体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应 1.05H,反应生成 2',3',5'-三乙酰尿苷
参考文献:Zhou; Welch; Chattopadhyaya,Acta Chemica Scandinavica. Series B: Organic Chemistry And Biochemistry,1986,Vol. 40,# 10,P. 806-816
标题:Zhou; Welch; Chattopadhyaya,Acta Chemica Scandinavica. Series B: Organic Chemistry And Biochemistry,1986,Vol. 40,# 10,P. 806-816

专利信息

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-5200514-A
优先权日:1990-01-19
标 题 :Synthesis of 2'-deoxypyrimidine nucleosides
发明人：CHU CHUNG K
权利人:UNIV GEORGIA RES FOUND
摘要:A method for the preparation of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides that includes the step of reacting a nucleoside having hydroxyl groups in the 2' and 3' positions with a mixture of acyl bromide or chloride and HX, wherein X is Br or Cl, at moderate temperature, to give a haloacyl nucleoside derivative that can be deprotected and reduced to form the desired compound.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.