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Azacitidine is a pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA...
Vujjini, Satish Kumar; Varanasi, Ganesh; Arevelli, Srinivas; Kandala, Sreenatha Charyulu; Tirumalaraju, Satyanarayana Raju; Bandichhor, Rakeshwar; Kagga, Mukkanti; Cherukupally, Praveen. An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug. Organic Process Research & Development. API-Research and Development, Integrated Product Development. Dr. Reddy's Laboratories Ltd. Bachupally, India 500072. Volume 17. Issue 2. Pages 303-306. 2013
Avanafil is a highly selective phosphodiesterase-5 (PDE5) inhibitor with potent in vitro activity, exhibiting an IC₅₀ of ~5 nM against human PDE5, while showing >100-fold selectivity over PDE6 and >10...
Sakamoto, Toshiaki; Koga, Yuichi; Hikota, Masataka; Matsuki, Kenji; Murakami, Michino; Kikkawa, Kohei; Fujishige, Kotomi; Kotera, Jun; Omori, Kenji; Morimoto, Hiroshi; Yamada, Koichiro. The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor. Bioorganic & Medicinal Chemistry Letters. Volume 24. Issue 23. Pages 5460-5465. Journal; Online Computer File. (2014).
Secnidazole, also known as SYM-1219, is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. It has also been tested against Atopobium vaginae.
Reference: Zeng, Yongfeng; Yi, Zhiheng. Method for synthesizing secnidazole. CN 103772289. (Hunan Dinuo Pharmaceutical Co., Ltd., Peop. Rep. China)
Ferric maltoll, sold under the brand names Accrufer and Feraccru, is for the treatment of adults with low iron stores. Ferric maltol (ST10): a novel oral iron supplement for the treatment of iron defi...
Mukha, S. A.; Antipova, I. A.; Medvedeva, S. A.; Saraev, V. V.; Larina, L. I.; Tsyrenzhapov, A. V.; Sukhov, B. G. Synthesis and properties of metal chelates from natural γ-pyrone maltol. Khimiya v Interesakh Ustoichivogo Razvitiya. Volume 15. Issue 4. Pages 457-466. Journal. (2007).
Sugammadex is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA). Sugammadex is a modified γ-cyclod...
Reference: Wang, Bingyong. Process for purification for the more glucose sodium that relaxes. CN 107778383.
Saxagliptin, also known as BMS-477118, is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin was approved in 2008 for the trea...
Dong, Jizhe; Gong, Yanchun; Liu, Jun; Chen, Xiangfeng; Wen, Xiaoan; Sun, Hongbin. Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry. Volume 22. Issue 4. Pages 1383-1393. 2014.
Pitolisant, also known as Tiprolisant, BF2649 and Ciproxidine, is a histamine receptor inverse agonist/antagonist selective for the H3 subtype. It has stimulant and nootropic effects and may have seve...
Reference: Qu, Chang; Liang, Chuang; Lu, Ying-xiang; Yang, Gui-qiu; Gong, Ping Zhongguo Yaowu Huaxue Zazhi. Synthesis of pitolisant as a histamine H3 receptor antagonist/invers Zhongguo Yaowu Huaxue Zazhi. Volume 23. Issue 2. Pages 111-114. Journal. (2013).
Doripenem Monohydrate, also known as S-4661 and Finibax, is a beta-lactam class drug used for bacterial infections with ultra-broad antibiotic spectrum. Doripenem Monohydrate is used commonly for the...
Zhang, Aiyan; Zhu, Xueyan; Yuan, Zhedong Zhongguo Yiyao Gongye Zazhi Volume 37 Issue 6 Pages 361-363 Journal 2006
Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR. In the presence of calcium ions, it can inhibit parathyroid hormone se...
Arava, Veera R.; Gorentla, Laxminarasimhulu; Dubey, Pramod K. A novel asymmetric synthesis of cinacalcet hydrochloride. Beilstein Journal of Organic Chemistry. R&D Laboratory. Suven Life Sciences Ltd. Hyderabad, India. Volume 8. Pages 1366-1373, No. 158. 2012
Maraviroc is an antiviral, potent, non-competitive CKR-5 receptor antagonist that inhibits binding of HIV viral coat protein gp120. Maraviroc inhibits MIP-1β-stimulated γ-S-GTP binding to HEK-293 cell...
Lou, Sha; Moquist, Philip N.; Schaus, Scott E. Asymmetric Allylboration of Acyl Imines Catalyzed by Chiral Diols. Journal of the American Chemical Society. Volume 129. Issue 49. Pages 15398-15404. 2007.
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