Azacitidine CAS# 320-67-2 阿扎胞苷
Azacitidine is a pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity.
📌 参考资料/链接：
Vujjini, Satish Kumar; Varanasi, Ganesh; Arevelli, Srinivas; Kandala, Sreenatha Charyulu; Tirumalaraju, Satyanarayana Raju; Bandichhor, Rakeshwar; Kagga, Mukkanti; Cherukupally, Praveen. An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug. Organic Process Research & Development. API-Research and Development, Integrated Product Development. Dr. Reddy's Laboratories Ltd. Bachupally, India 500072. Volume 17. Issue 2. Pages 303-306. 2013
Vujjini, Satish Kumar; Varanasi, Ganesh; Arevelli, Srinivas; Kandala, Sreenatha Charyulu; Tirumalaraju, Satyanarayana Raju; Bandichhor, Rakeshwar; Kagga, Mukkanti; Cherukupally, Praveen. An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug. Organic Process Research & Development. API-Research and Development, Integrated Product Development. Dr. Reddy's Laboratories Ltd. Bachupally, India 500072. Volume 17. Issue 2. Pages 303-306. 2013
📄 详细内容
CAS No. 320-67-2 阿扎胞苷Azacitidine synthetic routes
Vujjini, Satish Kumar; Varanasi, Ganesh; Arevelli, Srinivas; Kandala, Sreenatha Charyulu; Tirumalaraju, Satyanarayana Raju; Bandichhor, Rakeshwar; Kagga, Mukkanti; Cherukupally, Praveen. An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug. Organic Process Research & Development. API-Research and Development, Integrated Product Development. Dr. Reddy's Laboratories Ltd. Bachupally, India 500072. Volume 17. Issue 2. Pages 303-306. 2013
产品链接: CAS No. 320-67-2 ››
Vujjini, Satish Kumar; Varanasi, Ganesh; Arevelli, Srinivas; Kandala, Sreenatha Charyulu; Tirumalaraju, Satyanarayana Raju; Bandichhor, Rakeshwar; Kagga, Mukkanti; Cherukupally, Praveen. An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug. Organic Process Research & Development. API-Research and Development, Integrated Product Development. Dr. Reddy's Laboratories Ltd. Bachupally, India 500072. Volume 17. Issue 2. Pages 303-306. 2013
产品链接: CAS No. 320-67-2 ››