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Ozenoxacin CAS# 245765-41-7 奥泽沙星
Ozenoxacin, also known as GF-001001-00; M-5120; T-3912; GF-00100100, is an experimental quinolone antibiotic being developed for the treatment of impetigo and other dermatological bacterial infections...
Reference: Yu, Yang; Chen, Jingjin; Zhou, Huayin; Wang, Linyong; Zhang, Zhiqiang; Sun, Yuanjun; Qiu, Xin; Wang, Yuliang. Preparation method of intermediate of ozenoxacin antibacterial drug by Suzuki coupling reaction, and ozenoxacin from the intermediate. CN 108299480. (Assignee Shandong Bestcomm Pharmaceutical Co., Ltd., Peop. Rep. China)
Ceftobiprole medocaril sodium CAS# 252188-71-9 头孢比罗酯钠
Ceftobiprole medocaril (BAL5788) is a fifth-generation cephalosporin prodrug that exhibits potent in vitro and in vivo antimicrobial activity against a broad spectrum of Gram-positive and Gram-negativ...
Patent#: WO2010136423
Sparsentan CAS# 254740-64-2 4'-[(2-丁基-4-氧代-1,3-二氮杂螺[4.4]壬-1-烯-3-基)甲基]-N-(4,5-二甲基-3-异恶唑基)-2'-(乙氧基甲基)-[1,1'-联苯]-2-磺酰胺
Sparsentan, also known as RE-021, PS433540 and DARA-a, is a dual angiotensin II and endothelin A receptor antagonist. Sparsentan has demonstrated potent antagonism of ETA and AT1 receptors with Ki va...
Dual Angiotensin II and Endothelin A Receptor Antagonists: Synthesis of 2'-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and PharmacokineticsBy: Murugesan, Natesan; et alJournal of Medicinal Chemistry (2005), 48(1), 171-179
Aerobactin CAS# 26198-65-2 3-[[(1S)-5-(乙酰基-羟基-氨基)-1-羧基-戊基]氨基甲酰]-2-[[(1S)-5-(乙酰基-羟基-氨基)-1-羧基-戊基]氨基甲酰甲基]-2-羟基-丙酸
Aerobactin is a bacterial iron chelating agent (siderophore) found in E. coli. It is a virulence factor enabling E. coli to sequester iron in iron-poor environments such as the urinary tract. Aerobact...
1.1Catalysts:Copper sulfate;30 min, rt1.24 d, rt2.1Reagents:Sodium bicarbonateSolvents:Water;overnight, rt3.1Reagents:Thionyl chlorideSolvents:Ethanol;0 °C; 2 h, 0 °C; 0 °C → rt; overnight, rt4.1Solvents:Dichloromethane,Water;2 h, pH 10, 0 °C; 4 h, rt5.1Reagents:PyridineSolvents:Dichloromethane;4 h, 50 °C6.1Reagents:Hydrogen bromideSolvents:Acetic acid,Dichloromethane;40 min, rt7.1Reagents:Dicyclohexylcarbodiimide,N-HydroxysuccinimideSolvents:Tetrahydrofuran;30 min, rt7.2Solvents:Water;10 min, rt7.3Reagents:Sodium bicarbonateSolvents:Tetrahydrofuran;overnight, rt8.1Reagents:Trifluoroacetic acidSolvents:Dichloromethane;1 h, rt8.2Reagents:Sodium hydroxideSolvents:Tetrahydrofuran,Water;40 min, rt8.3Reagents:Hydrochloric acidSolvents:Water;pH 2, rt
Nirmatrelvir CAS# 2628280-40-8 帕罗韦德
Nirmatrelvir (PF-07321332) is a potent, selective, orally active inhibitor of the SARS-CoV-2 3CL protease (Mpro). In preclinical enzymatic assays, it inhibited Mpro with a Ki of ~3 nM and showed high ...
Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main ProteaseBy: Ngo, Chau; et alJournal of Medicinal Chemistry (2023), 66(17), 12237-12248
Suzetrigine CAS# 2649467-58-1 2-吡啶羧酰胺,4-[[[(2R,3S,4S,5R)-3-(3,4-二氟-2-甲氧基苯基)四氢-4,5-二甲基-5-(三氟甲基)-2-呋喃基]氨基]-
Suzetrigine, also known as VX-548, is a selective inhibitor of the voltage-gated sodium channel Nav1.7, being developed by Vertex Pharmaceuticals for the treatment of acute and neuropathic pain. It ex...
State-dependent inhibition of Nav1.8 sodium channels by VX-150 and VX-548By: Vaelli, Patric; et alMolecular Pharmacology (2024), 106(6), 298-308
Alcudacigib CAS# 2660218-70-0
Alcudacigib (ASP1570) is a small-molecule inhibitor of diacylglycerol kinase (DGK) developed to modulate tumor immunosuppression. In preclinical studies, it inhibited DGK activity in vitro and restore...
Preparation of pyridazinyl-thiazolecarboxamide compound as DGKζ inhibitorAssignees: Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.Inventors: Watanabe, Hideyuki; et alWorld Intellectual Property OrganizationPatent#WO2021132422 A1
Etravirine CAS# 269055-15-4 依曲韦林
Etravirine, also known as TMC 125 and R 165335, is a drug used for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It was also approved in 2008. Etraviri...
Process for the preparation of 4- [6-amino-5-bromo-2- [(4-cyanophenyl) amino]-4-pyrimidinyl]oxy]-3.5-dimethylbe nzonitrile (Etravirine); Rajan, Srinivasan Thirumalai; Eswaraiah, Sajja; Gutta, Madhusudhan; Peri, Seetha Rama Sarma; Assignee MSN Laboratories Private Limited, India; 2016; Patent Information; Apr 21, 2016; WO 2016059646 A2
Zongertinib CAS# 2728667-27-2
Zongertinib (BI 1810631) is an irreversible, oral HER2-selective tyrosine kinase inhibitor that demonstrates potent preclinical efficacy in HER2-driven cancers. It effectively inhibits tumor growth in...
Patent#: WO2021213800
Ticagrelor CAS# 274693-27-5 替卡格雷
Ticagrelor, also known as AZD-6140 and AR-C 126532XX, is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved in 2011. Ticagrelor is an antagonist of the P2Y12 receptor. Lik...
Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin. Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents. Bioorganic & Medicinal Chemistry Letters. Volume 22. Issue 11. Pages 3598-3602. Journal; Online Computer File. (2012).
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