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Avobenzone CAS# 70356-09-1 阿伏苯宗
Avobenzone is a dibenzoylmethane compound commonly found in sunscreens and can photoisomerize after exposure to near-ultraviolet light. At equilibrium, Avobenzone exists as a chelated enol characteriz...
Sun, Dong-Wei; Jiang, Min; Liu, Jin-Tao. Novel Bifunctionalization of Activated Methylene: Base-Promoted Trifluoromethylthiolation of β-Diketones with Trifluoromethanesulfinyl Chloride. Chemistry - A European Journal. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of, Organic Chemistry. University of Chinese Academy of Science, Chinese Academy of Science. Shanghai, Peop. Rep. China 200032. Volume 25. Issue 46. Pages 10797-10802. 2019
Pimavanserin CAS# 706779-91-1 2-胺基-5-(4-硝基苯磺酰)-噻唑
Pimavanserin, also known as ACP-103, is an inverse agonist on the serotonin receptor subtype 5-HT2A, with 40x selectivity over 5-HT2C, and no significant affinity or activity at 5-HT2B or dopamine rec...
Reference: Thygesen, Mikkel; Schlienger, Nathalie; Tolf, Bo-Ragnar; Blatter, Fritz; Berghausen, Jorg. Process for preparation of salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide. WO 2006036874. (Assignee ACADIA Pharmaceuticals Inc., USA)
Elacestrant CAS# 722533-56-4 艾拉司群
Elacestrant, also known as RAD1901, is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM). Elacestrant exhibits potent in vitro bioactivi...
Patent#: WO2004058682
Methylnaltrexone bromide CAS# 73232-52-7 溴甲纳曲酮
Methylnaltrexone, used in form of methylnaltrexone bromide (INN, USAN, BAN), is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opio...
Meng, Wenxue; Long, Daobing; Xiong, Dewang. Preparation method of methylnaltrexone bromide and intermediate thereof. Assignee Chongqing Landtower Pharmaceutical Co., Ltd., Peop. Rep. China. CN 107021978. (2017).
Elamipretide CAS# 736992-21-5 D-精氨酰-2,6-二甲基-L-酪氨酰-L-赖氨酰-L-苯丙氨酰胺
Elamipretide, also known as MTP 131, is a mitochondria-targeted peptide antioxidant. Elamipretide decreases inflammation and protect against a variety of neurological illnesses. Elamipretide (SS-31)...
Patent#: WO2015100376
Relugolix CAS# 737789-87-6 瑞卢戈利
Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally. Relugolix is a gonadotropin releasing hormone (GnRH) receptor antagonist t...
Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorBy: Miwa, Kazuhiro; et alJournal of Medicinal Chemistry (2011), 54(14), 4998-5012
Bempedoic acid CAS# 738606-46-7 贝派地酸
Bempedoic acid, also known as ESP-55016 and ETC-1002, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated w...
Synthesis of Bempedoic Acid through Electrochemical Decarboxylation of Dialkylated Malonic AcidBy: Xu, Zhimin; et alSynthesis (2021), 53(19), 3608-3612
Bempedoic Acid CAS# 738606-46-7 贝派地酸
Bempedoic acid, also known as ESP-55016 and ETC-1002, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated w...
Cilostazol CAS# 73963-72-1 西洛他唑
Cilostazol is a quinolinone-derivative medication used in the alleviation of the symptom of claudication in individuals with peripheral vascular disease. Cilostazol is a phosphodiesterase inhibitor wi...
Chandgude, Ajay L.; Doemling, Alexander. Convergent Three-Component Tetrazole Synthesis. European Journal of Organic Chemistry. Department of Drug Design. University of Groningen. Groningen, Neth. 9713 AV. Volume 2016. Issue 14.Pages 2383-2387. 2016
Argatroban CAS# 74863-84-6 阿加曲班(MCI-9038)
Argatroban is an anticoagulant that is a direct thrombin inhibitor. Argatroban was approved in 2000 for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). ...
Libralon, Giovanna; Nicole, Andrea; Zanon, Jacopo. Method for the preparation of argatroban monohydrate. Assignee Lundbeck Pharmaceuticals Italy S.p.A.. 2008.
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