Pimavanserin CAS# 706779-91-1 2-胺基-5-(4-硝基苯磺酰)-噻唑
Pimavanserin, also known as ACP-103, is an inverse agonist on the serotonin receptor subtype 5-HT2A, with 40x selectivity over 5-HT2C, and no significant affinity or activity at 5-HT2B or dopamine receptors. Pimavanserin is a novel drug candidate for Parkinson's psychosis.Parkinson's disease psychosis (PDP) is a condition that may develop in up to 60 % of Parkinson's patients, and is a major reason for nursing home placement for those affected.
📌 参考资料/链接：
Reference: Thygesen, Mikkel; Schlienger, Nathalie; Tolf, Bo-Ragnar; Blatter, Fritz; Berghausen, Jorg. Process for preparation of salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide. WO 2006036874. (Assignee ACADIA Pharmaceuticals Inc., USA)
Reference: Thygesen, Mikkel; Schlienger, Nathalie; Tolf, Bo-Ragnar; Blatter, Fritz; Berghausen, Jorg. Process for preparation of salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide. WO 2006036874. (Assignee ACADIA Pharmaceuticals Inc., USA)
📄 详细内容
CAS No. 706779-91-1 2-胺基-5-(4-硝基苯磺酰)-噻唑Pimavanserin synthetic routes
Thygesen, Mikkel; Schlienger, Nathalie; Tolf, Bo-Ragnar; Blatter, Fritz; Berghausen, Jorg. Process for preparation of salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide. WO 2006036874. (Assignee ACADIA Pharmaceuticals Inc., USA)
产品链接: CAS No. 706779-91-1 ››
Thygesen, Mikkel; Schlienger, Nathalie; Tolf, Bo-Ragnar; Blatter, Fritz; Berghausen, Jorg. Process for preparation of salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide. WO 2006036874. (Assignee ACADIA Pharmaceuticals Inc., USA)
产品链接: CAS No. 706779-91-1 ››