Relugolix CAS# 737789-87-6 瑞卢戈利
Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally. Relugolix is a gonadotropin releasing hormone (GnRH) receptor antagonist that decreases serum estradiol and progesterone concentrations to postmenopausal levels. Relugolix is effective in inducing a dose-dependent decrease in menstrual blood loss.
📌 参考资料/链接：
Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorBy: Miwa, Kazuhiro; et alJournal of Medicinal Chemistry (2011), 54(14), 4998-5012
Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorBy: Miwa, Kazuhiro; et alJournal of Medicinal Chemistry (2011), 54(14), 4998-5012
📄 详细内容
CAS No. 737789-87-6 瑞卢戈利Relugolix synthetic routes
Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorBy: Miwa, Kazuhiro; et alJournal of Medicinal Chemistry (2011), 54(14), 4998-5012
产品链接: CAS No. 737789-87-6 ››
Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorBy: Miwa, Kazuhiro; et alJournal of Medicinal Chemistry (2011), 54(14), 4998-5012
产品链接: CAS No. 737789-87-6 ››