Vigabatrin CAS# 60643-86-9 氨己烯酸
Vigabatrin, also known as gamma-vinyl-GABA, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of GABA transaminase (GABA-T). It is a structural analog of GABA, but does not bind to GABA receptors. Vigabatrin is an irreversible suicide inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of GABA, which increases the level of GABA in the brain. Vigabatrin is a racemic compound, and its [S]-enantiomer is pharmacologically active.
📌 参考资料/链接：
Deleris, G.; Dunogues, J.; Gadras, A. Direct regiospecific allylic amination via silicon induced pericyclic reactions. A novel synthesis of gamma vinyl GABA. Tetrahedron. Volume 44. Issue 13. Pages 4243-58. 1988.
Deleris, G.; Dunogues, J.; Gadras, A. Direct regiospecific allylic amination via silicon induced pericyclic reactions. A novel synthesis of gamma vinyl GABA. Tetrahedron. Volume 44. Issue 13. Pages 4243-58. 1988.
📄 详细内容
CAS No. 60643-86-9 氨己烯酸Vigabatrin synthetic routes
Deleris, G.; Dunogues, J.; Gadras, A. Direct regiospecific allylic amination via silicon induced pericyclic reactions. A novel synthesis of gamma vinyl GABA. Tetrahedron. Volume 44. Issue 13. Pages 4243-58. 1988.
产品链接: CAS No. 60643-86-9 ››
Deleris, G.; Dunogues, J.; Gadras, A. Direct regiospecific allylic amination via silicon induced pericyclic reactions. A novel synthesis of gamma vinyl GABA. Tetrahedron. Volume 44. Issue 13. Pages 4243-58. 1988.
产品链接: CAS No. 60643-86-9 ››