Triclabendazole CAS# 68786-66-3 三氯苯达唑
Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals suggest that triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes inhibition of spermatogenesis and vitelline cells.
📌 参考资料/链接：
Iddon, Brian; Kutschy, Peter; Robinson, Andrew G.; Suschitzky, Hans; Kramer, Walter; Neugebauer, Franz A. 2H-Benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), Issue 22, Pages 3129-34, 1992.
Iddon, Brian; Kutschy, Peter; Robinson, Andrew G.; Suschitzky, Hans; Kramer, Walter; Neugebauer, Franz A. 2H-Benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), Issue 22, Pages 3129-34, 1992.
