Trifluridine CAS# 70-00-8 曲氟尿苷
Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. It is a component of the experimental anti-cancer drug TAS-102.
📌 参考资料/链接：
Reference: Fernandez-Lucas, Jesus; Fresco-Taboada, Alba; Acebal, Carmen; Mata, Isabel; Arroyo, Miguel. Applied Microbiology and Biotechnology. Enzymatic synthesis of nucleoside analogues using immobilized 2'-deoxyribosyltransferase from Lactobacillus reuteriVolume. 91. Issue 2. Pages 317-327. Journal; Online Computer File (2011)
Reference: Fernandez-Lucas, Jesus; Fresco-Taboada, Alba; Acebal, Carmen; Mata, Isabel; Arroyo, Miguel. Applied Microbiology and Biotechnology. Enzymatic synthesis of nucleoside analogues using immobilized 2'-deoxyribosyltransferase from Lactobacillus reuteriVolume. 91. Issue 2. Pages 317-327. Journal; Online Computer File (2011)
📄 详细内容
CAS No. 70-00-8 曲氟尿苷Trifluridine synthetic routes
Fernandez-Lucas, Jesus; Fresco-Taboada, Alba; Acebal, Carmen; Mata, Isabel; Arroyo, Miguel. Applied Microbiology and Biotechnology. Enzymatic synthesis of nucleoside analogues using immobilized 2'-deoxyribosyltransferase from Lactobacillus reuteriVolume. 91. Issue 2. Pages 317-327. Journal; Online Computer File (2011)
产品链接: CAS No. 70-00-8 ››
Fernandez-Lucas, Jesus; Fresco-Taboada, Alba; Acebal, Carmen; Mata, Isabel; Arroyo, Miguel. Applied Microbiology and Biotechnology. Enzymatic synthesis of nucleoside analogues using immobilized 2'-deoxyribosyltransferase from Lactobacillus reuteriVolume. 91. Issue 2. Pages 317-327. Journal; Online Computer File (2011)
产品链接: CAS No. 70-00-8 ››