Acoltremon CAS# 68489-09-8 凉味剂WS-12

Acoltremon (WS-12) is a potent and selective TRPM8 agonist, demonstrating an EC₅₀ of approximately 39–193 nM, which is significantly more potent than menthol (EC₅₀ ≈ 196 µM) . In preclinical studies, WS-12 has been shown to induce a cooling sensation and activate TRPM8 channels in sensory neurons, leading to increased tear production and potential relief of dry eye symptoms . Additionally, encapsulation of WS-12 in lipid nanocapsules has been explored to enhance its delivery and efficacy in activating TRPM8 channels, potentially offering therapeutic benefits in conditions like dry eye disease and certain cancer types.