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工艺路线数据>>>Ceftolozane CAS# 689293-68-3 5-氨基-2-{(6R,7R)-7-(2Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(1-羧基-1-甲基氧基)亚胺乙酰胺-2-羧基-8-氧基-5-硫胺-1-氮基环4.2.0oct-2-烯-3-甲基甲基}-4-{(2-氨基乙基)氨基酰胺}-1-甲基-1H-吡氮唑-2-铀
Ceftolozane CAS# 689293-68-3 5-氨基-2-{(6R,7R)-7-(2Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(1-羧基-1-甲基氧基)亚胺乙酰胺-2-羧基-8-氧基-5-硫胺-1-氮基环4.2.0oct-2-烯-3-甲基甲基}-4-{(2-氨基乙基)氨基酰胺}-1-甲基-1H-吡氮唑-2-铀
Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics unless this enzyme is inhibited.
📌 参考资料/链接:
Fischer, Michael; Felzmann, Wolfgang. Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-ACA). Assignee Sandoz AG, Switz. WO 2017042188. (2017).
📄 详细内容
CAS No. 689293-68-3 5-氨基-2-{(6R,7R)-7-(2Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(1-羧基-1-甲基氧基)亚胺乙酰胺-2-羧基-8-氧基-5-硫胺-1-氮基环4.2.0oct-2-烯-3-甲基甲基}-4-{(2-氨基乙基)氨基酰胺}-1-甲基-1H-吡氮唑-2-铀Ceftolozane synthetic routes

Fischer, Michael; Felzmann, Wolfgang. Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-ACA). Assignee Sandoz AG, Switz. WO 2017042188. (2017).
产品链接: CAS No. 689293-68-3 ››