CAS: 689293-68-3; Ceftolozane Sulfate

专利信息

专利号:US-11059835-B2
优先权日:2014-08-15
标 题 :Synthesis of cephalosporin compounds
发明人：WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
权利人:MERCK SHARP & DOHME
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

专利号:US-10941161-B2
优先权日:2014-08-15
标 题:Intermediates in the synthesis of cephalosporin compounds
发明人：MOSHOS KRISTOS ADRIAN; JURKAUSKAS VALDAS; FOGLIATO GIOVANNI; SCANU MANUEL; HWANG YOU SEOK
权利人:MERCK SHARP & DOHME
摘要:Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.

专利号:US-9695196-B2
优先权日:2014-06-20
标 题 :Reactions of thiadiazolyl-oximinoacetic acid derivative compounds
发明人：MOSHOS KRISTOS ADRIAN; JURKAUSKAS VALDAS; SCANU MANUEL; BENOTTI MICHELE
权利人:MERCK SHARP & DOHME
摘要:This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.

专利号:US-2019225624-A1
优先权日:2014-08-15
标题:Intermediates in the synthesis of cephalosporin compounds

专利号:EP-3180347-B1
优先权日:2014-08-15
标 题:Synthesis of cephalosporin compounds

专利号:US-2018170949-A1
优先权日:2014-12-30
标 题 :Synthesis of cephalosporin compounds