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临床前CDMO研发化合物筛选
Mefenamic Acid
中文名称:甲灭酸
CAS号:61-68-7
分子式: C15H15NO2 分子量: 241.29
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteers
研究机构: Takeda
研发日期: October 14 2021
研发阶段: Phase 1
Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.
Oxytetracycline Dihydrate
中文名称:土霉素二水合物
CAS号:6153-64-6
分子式: C22H24N2O9.2H2O 分子量: 496.46
产品形式: Dihydrate
研发状态: Unknown status
研发用途: Acne Vulgaris II or III Degree; Boils
研究机构: Laboratorios Goulart S.A.
研发日期: May-10
研发阶段: Phase 3
Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Quercetin Dihydrate
中文名称:二水槲皮素
CAS号:6151-25-3
分子式: C15H10O7.2H2O 分子量: 338.27
产品形式: Dihydrate
研发状态: Recruiting
研发用途: Chronic Obstructive Pulmonary Disease; Emphysema; Chronic Bronchitis With Airway Obstruction
研究机构: Temple University; National Center for Complementary and Integrative Health (NCCIH); Quercegen Pharmaceuticals
研发日期: November 1 2023
研发阶段: Phase 2
Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
Menotropin
中文名称:尿促性素
CAS号:61489-71-2
分子式: C9H18O 分子量: 142.24
产品形式: free base
研发状态: Completed
研发用途: Infertility Female
研究机构: Ferring Pharmaceuticals
研发日期: November 4 2021
研发阶段: --
Menotropin (Human Menopausal Gonadotrophin) is a hormonally active medication for the treatment of fertility disturbances, which are extracted from the urine of postmenopausal women.
Procainamide HCl
中文名称:盐酸普鲁卡因胺
CAS号:614-39-1
分子式: C13H22ClN3O 分子量: 271.79
产品形式: Hydrochloride
研发状态: Completed
研发用途: Atrial Fibrillation
研究机构: Vanderbilt University Medical Center; National Heart Lung and Blood Institute (NHLBI)
研发日期: Nov-10
研发阶段: Not Applicable
Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.
Rolipram (ZK-62711)
中文名称:咯利普兰
CAS号:61413-54-5
分子式: C16H21NO3 分子量: 275.34
产品形式: free base
研发状态: Terminated
研发用途: Healthy Elderly Volunteers
研究机构: Dart NeuroScience LLC
研发日期: Sep-10
研发阶段: Phase 1
The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
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