临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 99755-59-6

Rotigotine

中文名称:罗替高汀
CAS号:99755-59-6
分子式: C19H25NOS 分子量: 315.47
产品形式: free base
研发状态: Completed
研发用途: Parkinson''s Disease
研究机构: Luye Pharma Group Ltd.
研发日期: May-16
研发阶段: Phase 1
Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

CAS: 99-66-1

Valproic acid (VPA)

中文名称:丙戊酸
CAS号:99-66-1
分子式: C8H16O2 分子量: 144.21
产品形式: free base
研发状态: Unknown status
研发用途: Drug Toxicity
研究机构: Mabaret Al-Asafara Hospitals
研发日期: Jun-21
研发阶段: Phase 4
Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.

CAS: 99614-01-4

Ondansetron HCl

中文名称:盐酸枢复宁
CAS号:99614-01-4
分子式: C18H19N3O.HCl 分子量: 329.82
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Post-operative Nausea and Vomiting
研究机构: Milton S. Hershey Medical Center
研发日期: February 1 2024
研发阶段: Phase 2
Ondansetron HCl (Ondemet, Emeset, Emetron,GR 38032F,SN 307) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.

CAS: 99592-39-9

Sertaconazole nitrate

中文名称:硝酸舍他康唑
CAS号:99592-39-9
分子式: C20H15Cl3N2OS.HNO3 分子量: 500.78
产品形式: Nitrate
研发状态: Unknown status
研发用途: Tinea Pedis; Athlete''s Foot; Foot Fungus; Ringworm
研究机构: Jamaica Hospital Medical Center; Johnson & Johnson
研发日期: Mar-09
研发阶段: Phase 3
Sertaconazole nitrate (FI-7045,FI7056) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.

CAS: 99300-78-4

Venlafaxine HCl

中文名称:文拉法辛盐酸盐
CAS号:99300-78-4
分子式: C17H27NO2.HCl 分子量: 313.86
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Major Depressive Disorder; Bipolar Affective Disorder Currently Depressed Moderate
研究机构: Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico
研发日期: March 1 2022
研发阶段: Phase 4
Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

CAS: 99-20-7

D-(+)-Trehalose Anhydrous

中文名称:D-海藻糖
CAS号:99-20-7
分子式: C12H22O11 分子量: 342.30
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteer Subjects
研究机构: Bioblast Pharma Ltd.; Parexel
研发日期: Mar-16
研发阶段: Phase 1
Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.