CAS: 99614-01-4; 9-Methyl-3-((2-Methyl-1H-Imidazol-1-yl)Methyl)-1,2,3,9-Tetrahydro-4H-Carbazol-4-One Hydrochloride

上下游产品

ondanserton 2-methylimidazole 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one bis-(dimethylamino)methaneondanserton

📜昂丹司琼置于盐酸体系中,用 水,异丙醇 作为反应溶剂,化学反应 1.0H,以49%的收率获得产物盐酸枢复宁
参考文献:Process For Preparing 1,2,3,9-Tetrahydro-9-Methyl-3-Methylene-4H-Carbazol-4-One And Ondansetron Therefrom
标题:Process For Preparing 1,2,3,9-Tetrahydro-9-Methyl-3-Methylene-4H-Carbazol-4-One And Ondansetron Therefrom
摘要:本发明提供了一种快速高产率的方法,用于从1,2,3,9-四氢-9-甲基-4H-咔唑-4-酮制备1,2,3,9-四氢-9-甲基-3-亚甲基-4H-咔唑-4-酮,而无需使用次级胺作为催化剂,也无需使用冰醋酸作作为反应溶剂.本发明还提供了一种快速高产率的方法,用于从1,2,3,9-四氢-9-甲基-3-亚甲基-4H-咔唑-4-酮制备奥替齐特,而无需使用氧化铝作为催化剂.

专利信息

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:MX-2009002267-A
优先权日:2006-08-28
标题:PROCEDURE AND INTERMEDIARIES FOR THE SYNTHESIS OF DERIVATIVES AND INTERMEDIARIES OF (3-ALQUIL-5-PIPERIDIN-1-IL-3,3A-DIHIDRO-PIRAZOLO [1,5-A] PIRIMIDIN-7-IL) -AMINO.

专利号:US-2007128285-A1
优先权日:2005-07-12
标题 :Pharmaceutical composition for oral administration
发明人：JIN CHIKARA; TATSUMI NOBORU; DAIRAKU MASATAKE; FUKUSHIMA FUMINORI; SHIMIZU TOSHIO; TOGASHI MITSUO; NINOMIYA HIROSHI
权利人:JIN CHIKARA; TATSUMI NOBORU; DAIRAKU MASATAKE; FUKUSHIMA FUMINORI; SHIMIZU TOSHIO; TOGASHI MITSUO; NINOMIYA HIROSHI
摘要:Provided is a pharmaceutical composition for oral administration containing a 5-HT. 3 receptor antagonist, which is suitable for self-medication because of good preservation stability, low synthesis, good uniformity and good external appearance, and good smoothness in throat, and easiness to be taken. Concretely, it is a jellied pharmaceutical composition for oral administration containing a 5-HT. 3 receptor antagonist, a gelatinizing agent, and water; and having a pH of 7 or less. In particular, there is provided the pharmaceutical composition, where the gelatinizing agent is carrageenan, pectin, agar, alginic acid, sodium alginate, gelatin, manna, Kodak, konjakmannan, glucomannan, chitosan, xanthan gum, tamarind seed polysaccharide, gellan gum, karaya gum, or cassia gum, or preferably the pharmaceutical composition further containing a thickener.

专利号:US-2022168402-A1
优先权日:2019-04-10
标题 :PIP4Ks SUPPRESS INSULIN SIGNALING AND ENHANCE IMMUNE FUNCTION THROUGH A CATALYTIC-INDEPENDENT MECHANISM
发明人：CANTLEY LEWIS C; PADDOCK MARCIA NOREEN; WANG DIANA GRACE
权利人:UNIV CORNELL
摘要:As described herein, phosphatidylinositol-5-phosphate 4-kinases (PIP4Ks) have an allosteric function in addition to their catalytic activity. The allosteric function suppresses PIP5K-mediated PI(4,5)P 2 synthesis and insulin-dependent conversion to PI(3,4,5)P 3 . Further described herein are methods for treatment of diabetes, metabolic syndrome, insulin resistance, a obesity, cancer, immune deficiency, autoimmune disease, infection, or a combination thereof.

专利号:CN-115677561-A
优先权日:2022-11-01
标 题:A kind of 1,2,3,4-tetrahydro-9-methyl-4H-carbazolone and its synthesis method