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临床前CDMO研发化合物筛选
Carvedilol Phosphate
中文名称:卡维地洛磷酸盐
CAS号:610309-89-2
分子式: C24H29N2O8P.1/2H2O 分子量: 513.48
产品形式: Phosphate
研发状态: Unknown status
研发用途: Endothelial Function; Diabetes Mellitus; Hypertension
研究机构: State University of New York - Downstate Medical Center
研发日期: Apr-08
研发阶段: Phase 4
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
Succinylcholine Chloride Dihydrate
中文名称: 氯化琥珀酰胆碱二水合物
CAS号:6101-15-1
分子式: C14H30N2O4.2Cl.2H2O 分子量: 397.34
产品形式: Chloride
研发状态: Unknown status
研发用途: Suxamethonium Sensitivity; Aspiration of Gastric Contents Into Respiratory Tract Part Unspecified
研究机构: University Hospital Caen
研发日期: November 6 2017
研发阶段: --
Succinylcholine Chloride Dihydrate (Suxamethonium) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
Tasimelteon
中文名称:他司美琼
CAS号:609799-22-6
分子式: C15H19NO2 分子量: 245.32
产品形式: free base
研发状态: Recruiting
研发用途: Autism Spectrum Disorder; Sleep Disorder; Neurological Disorder; Sleep Disturbance
研究机构: Vanda Pharmaceuticals
研发日期: July 28 2021
研发阶段: Phase 3
Tasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively).
Promethazine
中文名称:异丙嗪
CAS号:60-87-7
分子式: C17H20N2S 分子量: 284.42
产品形式: Free Base
研发状态: Recruiting
研发用途: Post-operative Nausea and Vomiting
研究机构: Milton S. Hershey Medical Center
研发日期: February 1 2024
研发阶段: Phase 2
Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
Apremilast (CC-10004)
中文名称:阿普斯特
CAS号:608141-41-9
分子式: C22H24N2O7S 分子量: 460.50
产品形式: free base
研发状态: Recruiting
研发用途: Plaque Psoriasis
研究机构: Bristol-Myers Squibb
研发日期: January 22 2024
研发阶段: --
Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.
SB742457
中文名称:英特匹定
CAS号:607742-69-8
分子式: C19H19N3O2S 分子量: 353.44
产品形式: free base
研发状态: Completed
研发用途: Alzheimer''s Disease
研究机构: GlaxoSmithKline
研发日期: July 4 2008
研发阶段: Phase 2
SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
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