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临床前CDMO研发化合物筛选
Binimetinib (MEK162)
中文名称:贝美替尼
CAS号:606143-89-9
分子式: C17H15BrF2N4O3 分子量: 441.23
产品形式: free base
研发状态: Not yet recruiting
研发用途: Colorectal Cancer
研究机构: Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD); Merck S.L. Spain; Pierre Fabre Ibérica S.A.
研发日期: January 19 2024
研发阶段: Phase 2
Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.
Selumetinib (AZD6244)
中文名称:司美替尼
CAS号:606143-52-6
分子式: C17H15BrClFN4O3 分子量: 457.68
产品形式: free base
研发状态: Not yet recruiting
研发用途: MPNST; NF1; Sarcoma
研究机构: University of Alabama at Birmingham; United States Department of Defense
研发日期: June 15 2024
研发阶段: Phase 2
Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.
Methimazole
中文名称:甲巯咪唑
CAS号:60-56-0
分子式: C4H6N2S 分子量: 114.17
产品形式: free base
研发状态: Unknown status
研发用途: Healthy
研究机构: Universidade Federal do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico
研发日期: Sep-11
研发阶段: Phase 4
Methimazole (Tapazole, Thiamazole) is an antithyroid medicine.
Cyclophosphamide (NSC-26271) Monohydrate
中文名称:环磷酰胺,一水
CAS号:6055-19-2
分子式: C7H15Cl2N2O2P.H2O 分子量: 279.10
产品形式: Monohydrate
研发状态: Active not recruiting
研发用途: Breast Cancer Female
研究机构: Mansoura University
研发日期: December 25 2023
研发阶段: Phase 2
Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.
Tetracycline
中文名称: 四环素
CAS号:60-54-8
分子式: C22H24N2O8 分子量: 444.43
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Acne Vulgaris
研究机构: Medical University of South Carolina
研发日期: Jan-25
研发阶段: Early Phase 1
Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
Bisacodyl
中文名称:比沙可啶
CAS号:603-50-9
分子式: C22H19NO4 分子量: 361.39
产品形式: free base
研发状态: Not yet recruiting
研发用途: Irritable Bowel Syndrome With Constipation
研究机构: Nanyang Technological University; National University of Singapore
研发日期: March 1 2024
研发阶段: Not Applicable
Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
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