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临床前CDMO研发化合物筛选
Sulfasalazine (NSC 667219)
中文名称:柳氮磺胺吡啶
CAS号:599-79-1
分子式: C18H14N4O5S 分子量: 398.39
产品形式: free base
研发状态: Recruiting
研发用途: Metastatic Colorectal Cancer
研究机构: Tanta University
研发日期: September 1 2023
研发阶段: Phase 3
Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.
Vicriviroc maleate
中文名称:Vicriviroc马来酸盐
CAS号:599179-03-0
分子式: C32H42F3N5O6 分子量: 649.70
产品形式: Maleate
研发状态: Completed
研发用途: Colorectal Neoplasms
研究机构: Merck Sharp & Dohme LLC
研发日期: September 24 2018
研发阶段: Phase 2
Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.
Cyclosporin A (NSC 290193)
中文名称:环孢霉素A
CAS号:59865-13-3
分子式: C62H111N11O12 分子量: 1202.61
产品形式: free base
研发状态: Not yet recruiting
研发用途: Esophageal Cancer; Exercise Training; Psychotherapy; Rehabilitation
研究机构: Mengmeng Yuan; Anhui Medical University
研发日期: May 1 2024
研发阶段: Not Applicable
Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Tenoxicam
中文名称:替诺昔康
CAS号:59804-37-4
分子式: C13H11N3O4S2 分子量: 337.38
产品形式: free base
研发状态: Completed
研发用途: Postoperative Pain Acute
研究机构: TC Erciyes University
研发日期: April 1 2018
研发阶段: Not Applicable
Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.
Brimonidine
中文名称: 溴莫尼定
CAS号:59803-98-4
分子式: C11H10BrN5 分子量: 292.13
产品形式: Free Base
研发状态: Completed
研发用途: Presbyopia
研究机构: Optall Vision
研发日期: June 1 2020
研发阶段: Phase 1
Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
Camostat Mesilate
中文名称:甲磺酸卡莫司他
CAS号:59721-29-8
分子式: C20H22N4O5.CH4O3S 分子量: 494.52
产品形式: Mesilate
研发状态: Terminated
研发用途: COVID-19 Infection
研究机构: Cancer Research UK; Latus Therapeutics
研发日期: September 23 2020
研发阶段: Phase 2
Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
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