CAS: 59721-29-8; 4-(2-(2-(Dimethylamino)-2-Oxoethoxy)-2-Oxoethyl)Phenyl 4-Guanidinobenzoate Methanesulfonate

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CAS号59721-16-3 2-(二甲基氨基)-2-氧代乙... | CAS号14658-93-6 2-羟基-N,N-二甲基乙酰胺 | CAS号71079-08-8 FOY 251 free base | CAS号156-38-7 对羟基苯乙酸 | CAS号16060-65-4 4-胍基苯甲酸

2-(二甲基氨基)-2-氧代乙基 2-(4-羟基苯基)乙酸酯置于碳酸氢钠体系中,用 吡啶,甲醇,乙醚 作为反应溶剂,化学反应生成 甲磺酸卡莫司他
参考文献:Guanidinobenzoic Acid Derivatives
标题:Guanidinobenzoic Acid Derivatives
摘要:由以下式(i)表示的胍基苯甲酸衍生物##str1##其中r.Sup.1,R.Sup.2和z如下文所定义,具有抗纤溶酶和抗胰蛋白酶活性,适用于合成的中间体以及制备相同的过程.

专利信息

专利号:US-2025188022-A1
优先权日:2022-02-07
标 题 :Process for the preparation of nafamostat, camostat and their derivatives
发明人：AHMED RIYAZ; KUMAR GULSHAN; MAHAJAN SHEENA; Verma Praveen Kumar; CHAM PANKAJ SINGH; KUMAR AMIT; AHMED QAZI NAVEED; REDDY DUMBALA SRINIVASA; SHANKAR RAVI; SINGH PARVINDER PAL
权利人:COUNCIL SCIENT IND RES
摘要:The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (Al) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.

专利号:US-2024002405-A1
优先权日:2022-06-01
标题 :Antimicrobial compounds, synthesis methods, and uses thereof
发明人：VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H
权利人:ANKH LIFE SCIENCES LTD
摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.