CAS: 609799-22-6; N-(((1R,2R)-2-(2,3-Dihydrobenzofuran-4-yl)Cyclopropyl)Methyl)Propionamide

上下游产品

((1R,2R)-2-(2,3-Dihydrobenzofuran-4-yl)Cyclopropyl)Methanamine
(Cis)-2-(2,3-Dihydrobenzofuran-4-yl)Cycloprop-1-Yl Methyl Amine
(1R,2R)-2-(2,3-Dihydro-1-Benzofuran-4-yl)Cyclopropane-1-Carbaldehyde
(1R,2R)-2-(2,3-Dihydro-1-Benzofuran-4-yl)-N-Methoxy-N-Methylcyclopropane-1-Carboxamide
(1R,2R)-2-(2,3-二氢-4-苯并呋喃基)环丙烷羧酸 (1R-Trans)-2-(2,3-Dihydro-4-Benzofuranyl)Cyclopropanecarboxylic Acid 452324-76-4
Ethyl (1R,2R)-2-(2,3-Dihydrobenzofuran-4-yl)Cyclopropane-1-Carboxylate

在 Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 2.0H,反应生成 他司美琼
参考文献:一种他司美琼的制备方法
标题:一种他司美琼的制备方法
摘要:本发明提供一种他司美琼的制备方法,至少包括以下步骤:化合物经取代反应或者磺化反应得到化合物ⅲ;然后与丙酰胺衍生物在碱性物质条件下反应得到他司美琼衍生物化合物ⅱ;最后化合物ⅱ脱除衍生基团得到他司美琼;具有路线短,收率高,纯度高,所用试剂均为常见试剂,整体成本低,工艺操作简单,适合工业化生产.

专利信息

专利号:WO-2018149940-A1
优先权日:2017-02-17
标题:Process for the preparation of enantiomerically enriched dihydrobenzofurans and intermediate compounds obtained in the process
发明人：BARRECA GIUSEPPE; POGGIALI ANDREA
权利人:QUIM SINTETICA S A
摘要:It is described an industrially viable and advantageous process for the preparation of (N- (((1R,2R)-2-(2,3-dihydrobenzofuran-4-yl)cyclopropyl)methyl)propionamide, compound having the formula depicted below and generally known as Tasimelteon, or of intermediates useful in the synthesis thereof: The invention also relates to salts obtained as intermediates of the process.

专利号:CN-106699707-A
优先权日:2015-07-22
标 题:Synthesis method of (1R,2R)-2-(2,3-dihydrobenzofuran-4-yl)cyclopropanemethanol, the key intermediate of tasimelteon