临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
如有产品调研服务, 请致函联系我们

客户展示

临床前CDMO研发化合物筛选

CAS: 623152-17-0

BMS-582949

中文名称:4-[[5-[(环丙基氨基)羰基]-2-甲基苯基]氨基]-5-甲基-N-丙基吡咯并[2,1-F][1,2,4]三嗪-6-甲酰胺
CAS号:623152-17-0
分子式: C22H26N6O2 分子量: 406.48
产品形式: free base
研发状态: Completed
研发用途: Rheumatoid Arthritis
研究机构: Bristol-Myers Squibb
研发日期: Nov-05
研发阶段: Phase 1
BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.

CAS: 620-67-7

Triheptanoin

中文名称:三庚酸甘油酯
CAS号:620-67-7
分子式: C24H44O6 分子量: 428.60
产品形式: Free Base
研发状态: Recruiting
研发用途: Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
研究机构: Ultragenyx Pharmaceutical Inc
研发日期: February 28 2023
研发阶段: Phase 3
Triheptanoin (API, IND106011, UX007, Glycerol trienanthate) is a synthetic, medium-chain triglyceride consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin is used for treatment of fatty acid oxidation disorders and GLUT1.

CAS: 6202-23-9

Cyclobenzaprine HCl

中文名称:5-(3-二甲氨基亚丙基)-二苯并[a,d]环庚三烯盐酸盐
CAS号:6202-23-9
分子式: C20H22ClN 分子量: 311.85
产品形式: Hydrochloride
研发状态: Completed
研发用途: Breast Reconstruction; Anesthesia; Transverse Abdominis Plane Block
研究机构: Vanderbilt University Medical Center
研发日期: June 13 2019
研发阶段: Phase 4
Cyclobenzaprine HCl(Cyclobenzaprine hydrochloride) is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms; A 5-HT2 receptor antagonist.

CAS: 620175-39-5

AFN-1252

中文名称:(2E)-N-甲基-N-[(3-甲基-2-苯并呋喃基)甲基]-3-(5,6,7,8-四氢-7-氧代-1,8-萘啶-3-基)-2-丙烯酰胺
CAS号:620175-39-5
分子式: C22H21N3O3 分子量: 375.42
产品形式: free base
研发状态: Completed
研发用途: Healthy Participants
研究机构: Debiopharm International SA
研发日期: June 14 2017
研发阶段: Phase 1
AFN-1252 (Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibits all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

CAS: 61-90-5

L-Leucine

中文名称:L-亮氨酸
CAS号:61-90-5
分子式: C6H13NO2 分子量: 131.17
产品形式: free base
研发状态: Recruiting
研发用途: B-All; Acute Lymphoblastic Leukemia
研究机构: National Cancer Institute (NCI); National Institutes of Health Clinical Center (CC)
研发日期: May 15 2024
研发阶段: Not Applicable
Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

CAS: 61-76-7

Phenylephrine (NCI-C55641) HCl

中文名称:盐酸去氧肾上腺素
CAS号:61-76-7
分子式: C9H13NO2.HCl 分子量: 203.67
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Anesthesia
研究机构: Ain Shams University
研发日期: October 5 2023
研发阶段: --
Phenylephrine HCl (NCI-c55641,Phenylephrine hydrochloride,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride) is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.