CAS: 620175-39-5; (E)-N-Methyl-N-((3-Methylbenzofuran-2-yl)Methyl)-3-(7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-yl)Acrylamide
- 英文名称(E)-N-Methyl-N-((3-Methylbenzofuran-2-yl)Methyl)-3-(7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-yl)Acrylamide
- 中文名称(2E)-N-甲基-N-[(3-甲基-2-苯并呋喃基)甲基]-3-(5,6,7,8-四氢-7-氧代-1,8-萘啶-3-基)-2-丙烯酰胺
- IUPAC名称(E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
- CAS编号620175-39-5
- MFCD编号:MFCD18633190
- FDA UNII编号:T3O718IKKM
- 分子式:C22H21N3O3分子量:375.43
- 产品CID: 2713696
- 同类组份化合物CAS1047981-31-6 (tosylate)620175-39-5 (free base)1047981-30-5 (tosylate hydrate)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
上下游产品
(E)-3-(7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-yl)Acrylic Acid 527758-08-3Tert-Butyl (E)-3-(7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-yl)Acrylate 527758-07-2
合成工艺路线路线简述
📜3-甲基苯并呋喃-2-碳酰氯置于lithium Aluminium Tetrahydride,1-羟基苯并三唑,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,N,N-二异丙基乙胺体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 26.0H,反应生成 (2E)-N-甲基-N-[(3-甲基-2-苯并呋喃基)甲基]-3-(5,6,7,8-四氢-7-氧代-1,8-萘啶-3-基)-2-丙烯酰胺
参考文献:Wo2008/98374
标题:Wo2008/98374
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902200000-苯
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zhou B, Pathania A, Pant D, Halpern D, Gaudu P, Trieu-Cuot P, Dias-Leao A, Pagot C, Solgadi A, Gruss A, Gloux K. Prophages divert Staphylococcus aureus defenses against host lipids. J Lipid Res. 2024 Dec;65(12):100693. doi: 10.1016/j.jlr.2024.100693. Epub 2024 Nov 5.
2: Jankov M, Léguillier V, Gašić U, Anba-Mondoloni J, Ristivojević MK, Radoičić A, Dimkić I, Ristivojević P, Vidic J. Antibacterial Activities of Agaricus bisporus Extracts and Their Synergistic Effects with the Antistaphylococcal Drug AFN-1252. Foods. 2024 May 30;13(11):1715. doi: 10.3390/foods13111715.
3: Pruitt EL, Zhang R, Ross DH, Ashford NK, Chen X, Alonzo F 3rd, Bush MF, Werth BJ, Xu L. Elucidating the impact of bacterial lipases, human serum albumin, and FASII inhibition on the utilization of exogenous fatty acids by Staphylococcus aureus. mSphere. 2023 Dec 20;8(6):e0036823. doi: 10.1128/msphere.00368-23. Epub 2023 Nov 28.
合成参考文献
参考文献:10.1007/s10928-017-9506-4
摘要:Bush K, Page MGP. What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles. Journal of Pharmacokinetics and Pharmacodynamics. 2017 Feb 04;44(2):113–32. doi: 10.1007/s10928-017-9506-4.
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