CAS: 6202-23-9; 3-(5H-Dibenzo[a,D][7]Annulen-5-Ylidene)-N,N-Dimethylpropan-1-Amine Hydrochloride

N,N-二甲基-3-氯丙胺置于盐酸,碘体系中,用 四氢呋喃,水,1,2-二溴乙烷 作为反应溶剂,化学反应 23.28H,反应生成 盐酸环苯扎林
参考文献:一种盐酸环苯扎林合成方法
标题:一种盐酸环苯扎林合成方法
摘要:本发明公开了一种盐酸环苯扎林合成方法,包括取重蒸四氢呋喃7‑10Ml置于100Ml三颈瓶中,投入碘1‑2粒,1,2‑二溴乙烷3‑5滴和锌粉0.7‑1.0G,缓慢加热至35oc恒温反应,反应时间为30‑40Min.本发明通过n,N‑二甲基‑3‑氯丙胺与碘,1,2‑二溴乙烷和锌粉在四氢呋喃中合成n,N‑二甲基‑3‑氯锌丙胺,并进一步与5H‑二苯并[a,D]环庚三烯‑5‑酮合成环苯扎林,利用其制备盐酸环苯扎林,并配合搅拌反应装置,反应控制技术和洗涤提纯方法,提高盐酸环苯扎林的品质和纯度,合成反应过程温和,安全性高,产品收率高且目标产物纯度高,方法简单易行,简捷快速,高效节能,适用于工业化大生产.

专利信息

专利号:US-9265748-B2
优先权日:2011-08-11
标题 :Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
发明人：RAILLARD STEPHEN P; MANTHATI SURESH K; JOSHI SUDHIR
权利人:XENOPORT INC
摘要:Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.

专利号:WO-2024097977-A1
优先权日:2022-11-04
标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery
发明人：SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S
权利人:TUFTS COLLEGE
摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.

专利号:US-2024091199-A1
优先权日:2017-06-30
标 题:Deuterated Domperidone Compositions, Methods, and Preparation
发明人：PEARCE CATHERINE; ISAACSOHN JON; PATEL PIYUSH
权利人:CINDOME PHARMA INC
摘要:Deuterated domperidone compositions, methods of synthesis, methods of use, and dosing formulations providing beneficial safety and other effects.

专利号:US-2015313865-A1
优先权日:2011-08-11
标 题:Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use

专利号:US-2014066501-A1
优先权日:2011-08-11
标 题:Anhydrous and Hemihydrate Crystalline Forms of an (R)-Baclofen Prodrug, Methods of Synthesis and Methods of Use

专利号:US-8580850-B2
优先权日:2011-08-11
标题 :Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use