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临床前CDMO研发化合物筛选
Naporafenib (LXH254)
CAS号:1800398-38-2
分子式: C25H25F3N4O4 分子量: 502.49
产品形式: Free Base
研发状态: Active not recruiting
研发用途: Melanoma
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: October 30 2020
研发阶段: Phase 2
Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.
Lanraplenib (GS-9876)
CAS号:1800046-95-0
分子式: C23H25N9O 分子量: 443.50
产品形式: Free Base
研发状态: Terminated
研发用途: Acute Myeloid Leukemia; Relapsed Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
研究机构: Kronos Bio
研发日期: August 5 2022
研发阶段: Phase 1 : Phase 2
Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
Tolinapant (ASTX660)
CAS号:1799328-86-1
分子式: C30H42FN5O3 分子量: 539.68
产品形式: Free base
研发状态: Recruiting
研发用途: Advanced Cancer; Cervical Cancer; Triple Negative Breast Cancer
研究机构: Institute of Cancer Research United Kingdom; Astex Pharmaceuticals Inc.; Merck Sharp & Dohme LLC; Cancer Research UK
研发日期: March 2 2022
研发阶段: Phase 1
Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.
Prucalopride Succinate
中文名称: 琥珀酸普卡必利
CAS号:179474-85-2
分子式: C18H26ClN3O3.C4H6O4 分子量: 485.96
产品形式: Succinat
研发状态: Recruiting
研发用途: Chronic Constipation
研究机构: Takeda; UC San Diego Human Milk Research Biorepository
研发日期: March 2 2022
研发阶段: --
Prucalopride(R-108512) is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively.
Prucalopride
中文名称:普芦卡必利
CAS号:179474-81-8
分子式: C18H26ClN3O3 分子量: 367.87
产品形式: Free Base
研发状态: Recruiting
研发用途: Chronic Constipation
研究机构: Takeda; UC San Diego Human Milk Research Biorepository
研发日期: March 2 2022
研发阶段: --
Prucalopride (R-93877) is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.
Caspofungin (MK-0991) Acetate
中文名称:醋酸卡泊芬净
CAS号:179463-17-3
分子式: C52H88N10O15.2C2H4O2 分子量: 1213.42
产品形式: diacetate
研发状态: Unknown status
研发用途: Critical Illness; Extracorporeal Membrane Oxygenation Complication; Infection
研究机构: Royal Brompton & Harefield NHS Foundation Trust
研发日期: September 3 2018
研发阶段: --
Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.
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