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临床前CDMO研发化合物筛选
Eletriptan HBr
中文名称:依来曲普坦氢溴酸盐
CAS号:177834-92-3
分子式: C22H26N2O2S.HBr 分子量: 463.43
产品形式: HBr
研发状态: Completed
研发用途: Migraine
研究机构: Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.; Pfizer
研发日期: Mar-05
研发阶段: Phase 4
Eletriptan (UK-116044) is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.
Ambrisentan
中文名称:安倍生坦
CAS号:177036-94-1
分子式: C22H22N2O4 分子量: 378.42
产品形式: free base
研发状态: Completed
研发用途: Sickle Cell Anemia
研究机构: Augusta University; Gilead Sciences; National Heart Lung and Blood Institute (NHLBI)
研发日期: Sep-15
研发阶段: Phase 1
Ambrisentan (LU-208075, BSF-208075) is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).
Abametapir
中文名称:5 5'-二甲基-2,2'-联吡啶
CAS号:1762-34-1
分子式: C12H12N2 分子量: 184.24
产品形式: Free Base
研发状态: Completed
研发用途: Head Lice Infestation
研究机构: Dr. Reddy''s Laboratories Limited
研发日期: Apr-13
研发阶段: Phase 2
Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.
Valganciclovir HCl
中文名称:缬更昔洛韦盐酸盐
CAS号:175865-59-5
分子式: C14H22N6O5.HCl 分子量: 390.82
产品形式: Hydrochloride
研发状态: Not yet recruiting
研发用途: Cytomegalovirus Infections; Kidney Transplant Infection; Pancreas Transplant
研究机构: University of Wisconsin Madison; Merck Sharp & Dohme LLC
研发日期: May-24
研发阶段: Phase 3
Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.
Metolazone
中文名称:美托拉宗
CAS号:17560-51-9
分子式: C16H16ClN3O3S 分子量: 365.83
产品形式: free base
研发状态: Unknown status
研发用途: Acute Decompensated Heart Failure; Diuretics Resistance
研究机构: Cairo University; Kasr El Aini Hospital
研发日期: March 31 2019
研发阶段: Not Applicable
Metolazone (SR 720-22) is a diuretic that primarily used to treat congestive heart failure and high blood pressure.
Voreloxin (SNS-595) hydrochloride
中文名称:(3S-反式)-1,4-二氢-7-[3-甲氧基-4-(甲基氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸单盐酸盐
CAS号:175519-16-1
分子式: C18H20ClN5O4S 分子量: 437.90
产品形式: hydrochloride
研发状态: Active not recruiting
研发用途: Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Acute Myeloid Leukemia With Multilineage Dysplasia; Myeloid Sarcoma; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia; Therapy-Related Myelodysplastic Syndrome
研究机构: Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)
研发日期: Mar-16
研发阶段: Phase 2
Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
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