2-羟基-5-甲基嘧啶置于三溴化磷,铜体系中,化学反应生成5 5'-二甲基-2,2'-二吡啶 参考文献:The Synthesis Of Certain Substituted 2,2'-Bipyridyls1 标题:The Synthesis Of Certain Substituted 2,2'-Bipyridyls1 摘要: Doi:10.1021/ja01216A045
专利号:US-8153839-B2 优先权日:2005-09-14 标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound 发明人:OGO SEIJI; FUKUZUMI SHUN-ICHI 权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY 摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.
专利号:US-2021107859-A1 优先权日:2018-04-06 标题 :A process for the synthesis of carbon labeled organic compounds 发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.
专利号:EP-3549927-A1 优先权日:2018-04-06 标 题:A process for the synthesis of carbon labeled organic compounds
专利号:WO-2019193068-A1 优先权日:2018-04-06 标 题:A process for the synthesis of carbon labeled organic compounds
专利号:US-8951400-B2 优先权日:2007-10-17 标题:Chemistry used in biosensors 发明人:AHRENS MICHAEL; BERTIN PAUL A; GRAY HARRY B; MEADE THOMAS J 权利人:AHRENS MICHAEL; BERTIN PAUL A; GRAY HARRY B; MEADE THOMAS J; OHMX CORP 摘要:The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
专利号:US-9884316-B2 优先权日:2014-03-10 标题:Mononuclear ruthenium complex and organic synthesis reaction using same 发明人:NAGASHIMA HIDEO; SUNADA YUSUKE; OGUSHI HAJIME; SAKUTA KOJI 权利人:UNIV KYUSHU NAT UNIV CORP; SHINETSU CHEMICAL CO 摘要:A neutral or cationic mononuclear ruthenium divalent complex represented by formula (1) can actualize exceptional catalytic activity in at least one reaction among a hydrosilylation reaction, hydrogenation reaction, and carbonyl compound reduction reaction. n n(In the formula, R 1 -R 6 each independently represent a hydrogen atom or an alkyl group, aryl group, aralkyl group, organooxy group, monoorganoamino group, diorganoamino group, monoorganophosphino group, diorganophosphino group, monoorganosilyl group, diorganosilyl group, triorganosilyl group, or organothio group optionally substituted by X; at least one pair comprising any of R 1 -R 3 and any of R 4 -R 6 together represents a crosslinkable substituent; X represents a halogen atom, organooxy group, monoorganoamino group, diorganoamino group, or organothio group; L each independently represent a two-electron ligand other than CO and thiourea ligands; two L may bond to each other; and m represents an integer of 3 or 4.)
1: Woods AD, Porter CL, Feldman SR. Abametapir for the Treatment of Head Lice: A Drug Review. Ann Pharmacother. 2022 Mar;56(3):352-357. doi: 10.1177/10600280211027968. Epub 2021 Jun 22. 106(1):91-92. 33(4):410-415. doi: 10.1097/MOP.0000000000001031. 35(5):616-621. doi: 10.1111/pde.13612. Epub 2018 Jul 12. 5: Bowles VM, Yoon KS, Barker SC, Tran C, Rhodes C, Clark MJ. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan;54(1):167-172. doi: 10.1093/jme/tjw132. Epub 2016 Aug 21. Erratum in: J Med Entomol. 2017 Jan 1;54(1):248. 6: Bowles VM, Hanegraaf S, Ahveninen T, Sidgiddi S, Allenby K, Alsop H. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019 Feb 22;6:2333794X19831295. doi: 10.1177/2333794X19831295.
合成参考文献
参考文献:10.1107/s1600536811010579 摘要:Ji L, Liu J, Song W. Bis(2,4-dichlorophenoxyacetato-κ2O1,O1′)(5,5′-dimethyl-2,2′-bipyridine-κ2N,N′)cobalt(II). Acta Crystallogr E Struct Rep Online. 2011 Mar 26;67(4):m493. doi: 10.1107/s1600536811010579. 参考文献:10.1107/s1600536811011305 摘要:Phatchimkun J, Chaichit N. Diazidobis(5,5′-dimethyl-2,2′-bipyridyl-κ2N,N′)cobalt(II) monohydrate. Acta Crystallogr E Struct Rep Online. 2011 Mar 31;67(4):m516–7. doi: 10.1107/s1600536811011305. 参考文献:10.1107/s1600536811013353 摘要:Ji L, Liu J, Song W. (5,5′-Dimethyl-2,2′-bipyridine-κ2N,N′)(1-naphthylacetato-κO)(1-naphthylacetato-κ2O,O′)zinc hemihydrate. Acta Crystallogr E Struct Rep Online. 2011 Apr 16;67(5):m606. doi: 10.1107/s1600536811013353. 参考文献:10.1107/s1600536811014085 摘要:Lundvall F, Wragg DS, Tilset M. (5,5'-Dimethyl-2,2'-bipyridine)-iodido-trimethyl-platinum(IV). Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):m617–8.