CAS: 179474-81-8; 4-Amino-5-Chloro-N-(1-(3-Methoxypropyl)Piperidin-4-yl)-2,3-Dihydrobenzofuran-7-Carboxamide

上下游产品

ethyl 1-(3-methoxy-propyl)-piperidin-4-carboxylate 4-amino-1-(3-methoxypropyl)piperidine 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid methyl esterprucalopride succinate

Methyl-1-(3-Methoxypropyl)Piperidine-4-Carboxylate置于ammonium Hydroxide,1,3-二溴-5,5-二甲基海因,N,N'-羰基二咪唑,Potassium Hydroxide体系中,用 四氢呋喃,水,乙腈 用作溶剂,化学反应 17.42H,反应生成普卡必利
参考文献:一种制备普卡必利中间体的新工艺
标题:一种制备普卡必利中间体的新工艺
摘要:本发明公开了一种式(I)所示的1‑(3‑甲氧丙基)‑4‑哌啶胺的制备方法,其包括如下列步骤:(1)将式(II)化合物在氨的溶液中反应制得式(III)化合物;(2)将式(III)化合物与1,3‑二溴‑5,5‑二甲基海因在碱性条件下反应制得式(I)化合物.本制备方法无特殊反应设备要求,操作简便,适于工业化生产;收率高,三废少,成本低;产品化学纯度高,无重金属残留问题.

专利信息

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:CN-105294620-A
优先权日:2014-06-16
标题 :Synthesis of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid

专利号:CN-103804211-A
优先权日:2014-03-12
标题:Synthesis of 4-(acetylamino)-2-hydroxy-3-(2-carbonylethyl)methyl benzoate

专利号:CN-104016949-A
优先权日:2014-06-25
标题 :Synthesis of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

专利号:US-8691836-B2
优先权日:2010-06-18
标题 :D2 antagonists, methods of synthesis and methods of use