项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

SC-435

Chemical Name: 1-[4-[4-[3,3-Dibutyl-7-(dimethylamino)-4(R)-hydroxy-1,1-dioxido-2,3,4,5-tetrahydro-1-benzothiepin-5(R)-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane methanesulfonate
CAS No. 2...
参考文献标题:Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
文献作者:Manning,R.E.; Tremont,S.J.; Glenn,K.C.; Keller,B.T.(Pharmacia Corp.)
参考来源:WO 0168096

AR-C102222

Chemical Name: 5-(4'-Amino-5',8'-difluoro-1',2'-dihydrospiro[piperidine-4,2'-quinazoline]-1-ylcarbonyl)pyridine-2-carbonitrile
CAS No. 253771-21-0, 190010-48-1 (diHCl)
项目整合开发状态: Preclinical
项...
参考文献标题:Pharmaceutically active quinazoline cpds.
文献作者:Hamley,P.R.J.; Pimm,A.D.; Tinker,A.C.; Beaton,H.G.; McInally,T.(AstraZeneca plc)
参考来源:EP 0858451; JP 1999513679; WO 9714686

(+)-Deoxoartelinic acid

Chemical Name: (+)-4-[2-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethylperhydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepin-10-yl]ethyl]benzoic acid; (+)-10(R)-[2-(4-Carboxyphenyl)ethyl]-10-deoxoartemi...
参考文献标题:Method of preparing (+)-deoxoartemisinin and selected analogues of (+)-deoxoartemisinin
文献作者:McChesney,J.D.; Jung,M.
参考来源:US 5225562

PTX-031553

Chemical Name: 5-Chloro-2-(4-chloro-3-nitrophenylsulfonamido)-N-(4-chlorophenyl)benzamide
CAS No. 136402-17-0
项目整合开发状态: Biological Testing
项目研究机构: PanTherix (Originator)
合成路线:Condensation ...
参考文献标题:Bactericidal benzamide derivs.
文献作者:Allanson,N.M.; Thomas,M.G.(PanTherix Ltd.)
参考来源:GB 2365426

INF BCP, INF-401

Chemical Name: Phenylacetic acid N'-(2-hydroxy-1-naphthylmethylene)hydrazide
CAS No. 34334-88-8
项目整合开发状态: Biological Testing
项目研究机构: Influx (Originator)
合成路线:The title N-acyl hydrazone is ...
参考文献标题:Certain 2-hydroxy-1-naphthaldehyde acylhydrazones and their use as fungicides
文献作者:Rusay,R.J.
参考来源:US 4277500

新产品编号:946545

Chemical Name: [10-[N-[6-[5-[(3aS,4S,6aR)-2-Oxoperhydrothieno[3,4-d]imidazol-4-yl]pentylamino]hexyl]carbamoylmethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)][90Y]yttrium(3+)
CAS No. 451...
参考文献标题:Aminoderivs.of biotin and their conjugates with macrocyclic chelating agents
文献作者:Paganelli,G.; Chinol,M.; Ginanneschi,M.(Sigma-Tau Industrie Farmaceutiche Riunite SpA)
参考来源:WO 0266075

CT-32228

Chemical Name: N-(4-Bromophenyl)-6-(5-chloro-2-methylphenyl)-1,3,5-triazine-2,4-diamine
CAS No. 521064-34-6
项目整合开发状态: Preclinical
项目研究机构: Cell Therapeutics (Originator)
合成路线:The cyclizatio...
参考文献标题:6-Phenyl-N-phenyl-(1,3,5)-triazine-2,4-diamine derivs.and related cpds.with lysophosphatidic acid acyltransferase beta (LPAAT-beta) inhibitory activity for use in the treatment of cancer
文献作者:Klein,J.P.; Gong,B.; Kumar,A.M.; Bhatt,R.; Tulinsky,J.; Hong,F.; Jenkins,S.A.(Cell Therapeutics,Inc.)
参考来源:US 2003153570; WO 0337346

新产品编号:174529

Chemical Name: 2',3'-O-Diacetyl-5'-[N-[4-amino-2(Z)-butenyl]-N-methylamino]-5'-deoxyadenosine
CAS No. 183277-44-3
项目整合开发状态: Preclinical
项目研究机构: Pace University (Originator), Roswell Park Canc...
参考文献标题:Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth,trypanosomal growth,and HIV-1 infectivity
文献作者:Marasco,C.J.; Kramer,D.L.; Miller,J.; Porter,C.W.; Bacchi,C.J.; Rattendi,D.; Kucera,L.; Iyer,N.; Bernacki,R.; Pera,P.; Sufrin,J.R.
参考来源:J Med Chem 2002,45(23),5112

RTI-4229-336, RTI-336

Chemical Name: (exo,exo)-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)isoxazol-5-yl]-8-azabicyclo[3.2.1]octane hydrochloride
CAS No. 204069-50-1, 236754-02-2 (free base)
项目整合开发状态: Preclinica...
参考文献标题:Cocaine receptor binding ligands
文献作者:Kuhar,M.J.; Carroll,F.I.; Boja,J.W.; Lewin,A.H.; Abraham,P.(Research Triangle Institute)
参考来源:EP 0993301; JP 2001525795; US 6531483; WO 9807427

新产品编号:742467

Chemical Name: Nitric acid 3-[2-(4-biphenylyl)-4-methylmorpholin-2-yloxy]propyl ester hydrobromide
CAS No. 283168-16-1 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Aristotle University of Th...
参考文献标题:Hypolipidemic and antioxidant morpholine derivs.
文献作者:Chrysselis,M.; Rekka,E.; Kourounakis,P.(Elpen Pharm.Co.)
参考来源:CA 2359476; EP 1140877; US 6693192; WO 0042030