项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

EP-1112

Chemical Name: Acetic acid (4R,5S,6S,7R,9R,10R,14R)-6-[3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methylbutyryl)-alpha-L-ribo-hexopyranosyl]-3-(dimethylamino)-beta-D-glucopyranosyl]-10-(dimethylam...
参考文献标题:9-Amino derivatives of novel 14-membered ring macrolide antibiotics derived from leucomycins: Chemistry and in vitro biological activities
文献作者:Vo,N.H.; Wang,J.; Haley,T.; Napper,A.; Phan,L.T.; Or,Y.
参考来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002,San Diego) 2002,Abst F-1664

SB-656104(free base), SB-656104-A

Chemical Name: 6-[2(R)-[2-[4-(4-Chlorophenoxy)piperidin-1-yl]ethyl]pyrrolidin-1-ylsulfonyl]-1H-indole hydrochloride
CAS No. 446020-51-5 (free base)
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKli...
参考文献标题:Sulfonamide cpds.,their preparation and use
文献作者:Forbes,I.T.; Gribble,A.D.(GlaxoSmithKline plc)
参考来源:WO 0262788

Deoxynegamycin, VRC-3573

Chemical Name: 2-[2-[3(R),6-Diaminohexanoyl]-1-methylhydrazino]acetic acid; 3(R),6-Diaminohexanoic acid 2-(carboxymethyl)-2-methylhydrazide
CAS No. 58773-33-4
项目整合开发状态: Preclinical
项目研究机构: Vi...
参考文献标题:delta-Substd.negamycin derivs.and syntheses
文献作者:Umezawa,H.; Kondo,S.(Microbial Chemistry Research Foundation)
参考来源:US 4065495

新产品编号:933889

Chemical Name: 1-[3-Benzyl-5-(1,1-dioxoisothiazolidin-2-ylmethyl)phenyl]-1-(8-hydroxy-1,6-naphthyridin-7-yl)methanone
CAS No. 422550-94-5
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator...
参考文献标题:Aza- and polyaza-naphthalenyl ketones useful as HIV integrase inhibitors
文献作者:Young,S.D.; Guare,J.P.; Wai,J.S.; Payne,L.S.; Fisher,T.E.; Zhuang,L.; Embrey,M.(Merck & Co.,Inc.)
参考来源:WO 0236734

新产品编号:872191

Chemical Name: N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonyl-glycyl-N5-(1H-imidazol-2-ylmethyl)-L-ornithyl-L-aspartyl-D-alanyl-L-aspartyl-glycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthr...
参考文献标题:Lipopeptides as antibacterial agents
文献作者:Watson,A.D.; Hill,J.; Zhang,Y.; Finn,J.; Yu,X.Y.; Keith,D.; Morytko,M.; Parr,I.; Siedlecki,J.; Silverman,J.; Christensen,D.; Lazarova,T.(Cubist Pharmaceuticals,Inc.)
参考来源:WO 0144274

(+)-AC-7954

Chemical Name: (+)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
CAS No. 477313-11-4, 477313-10-3 (enantiomer), 477313-09-0 (non-specific stereoch.)<...
参考文献标题:Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-Chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954)
文献作者:Croston,G.E.; Olsson,R.; Currier,E.A.; Burstein,E.S.; Weiner,D.; Nash,N..; Severance,D.; Allenmark,S.G.; Thunberg,L.; Ma,J.-N.; Mohell,N.; O'Dowd,B.; Brann,M.R.; Hacksell,U.
参考来源:J Med Chem 2002,45(23),4950

RTI-7527-33

Chemical Name: exo-5-(7-Azabicyclo[2.2.1]hept-2-yl)-2-chloropyridin-3-amine hydrochloride
CAS No. 426460-45-9 (free base)
项目整合开发状态: Preclinical
项目研究机构: Research Triangle Institute (Originator...
参考文献标题:Cpds.and methods for promoting smoking cessation
文献作者:Carroll,F.I.(Research Triangle Institute)
参考来源:US 6538010; WO 0237927

新产品编号:834223

Chemical Name: 2-[2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)quinolin-4-ylamino]ethanol
CAS No. 332181-97-2, 332180-41-3 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:Re...
参考文献标题:4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
文献作者:Pinard,E.; Alanine,A.; Bourson,A.; Buttelman,B.; Heitz,M.-P.; Mutel,V.; Gill,R.; Trube,G.; Wyler,R.
参考来源:Bioorg Med Chem Lett 2002,12(18),2615

TX-1925

Chemical Name: 2-(3,5-Di-tert-butyl-4-methoxybenzylidene)-4-cyclopentene-1,3-dione
CAS No. 503473-31-2
项目整合开发状态: Biological Testing
项目研究机构: National Institute Infectious Diseases (Originator)...
参考文献标题:TX-1123: An antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity
文献作者:Hori,H.; Nagasawa,H.; Ishibashi,M.; Uto,Y.; Hirata,A.; Saijo,K.; Ohkura,K.; Kirk,K.L.; Uehara,Y.
参考来源:Bioorg Med Chem 2002,10(10),3257

新产品编号:657039

Chemical Name: (Z)-2-[4-(5-Methyl-2-phenyloxazol-4-ylmethoxy)benzyloxyimino]-2-(4-phenoxyphenyl)acetic acid
CAS No. 250601-08-2, 250601-09-3 (E-isomer)
项目整合开发状态: Preclinical
项目研究机构: Takeda (O...
参考文献标题:Oxyiminoalkanoic acid derivs.with hypoglycemic and hypolipidemic activity
文献作者:Kimura,H.; Momose,Y.; Odaka,H.; Sakamoto,J.; Imoto,H.(Takeda Chemical Industries,Ltd.)
参考来源:EP 1077957; JP 2000034266; JP 2000198772; US 6251926; US 6495581; WO 9958510