(+)-AC-7954
Chemical Name: (+)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
CAS No. 477313-11-4, 477313-10-3 (enantiomer), 477313-09-0 (non-specific stereoch.)
项目整合开发状态: Biological Testing
项目研究机构: ACADIA (Originator)
合成路线:Addition of the dilithium salt of N-methyl-o-toluamide (I) to 4-chloro-3'-(dimethylamino)propiophenone (II) produces intermediate (III).Cyclization of (III) in refluxing o-dichlorobenzene generates the target isobenzochromanone compound,which is finally isolated as the corresponding hydrochloride salt
📌 参考资料/链接：
参考文献标题:Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-Chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954)
文献作者:Croston,G.E.; Olsson,R.; Currier,E.A.; Burstein,E.S.; Weiner,D.; Nash,N..; Severance,D.; Allenmark,S.G.; Thunberg,L.; Ma,J.-N.; Mohell,N.; O'Dowd,B.; Brann,M.R.; Hacksell,U.
参考来源:J Med Chem 2002,45(23),4950