TX-1925
Chemical Name: 2-(3,5-Di-tert-butyl-4-methoxybenzylidene)-4-cyclopentene-1,3-dione
CAS No. 503473-31-2
项目整合开发状态: Biological Testing
项目研究机构: National Institute Infectious Diseases (Originator), National Institutes of Health (Originator), University of Tokushima (Originator)
合成路线:The title compound is prepared by condensation of 3,5-di-t-butyl-4-methoxybenzaldehyde (I) with cyclopentene-1,3-dione (II) in the presence of p-toluenesulfonic acid in refluxing chloroform.
📌 参考资料/链接：
参考文献标题:TX-1123: An antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity
文献作者:Hori,H.; Nagasawa,H.; Ishibashi,M.; Uto,Y.; Hirata,A.; Saijo,K.; Ohkura,K.; Kirk,K.L.; Uehara,Y.
参考来源:Bioorg Med Chem 2002,10(10),3257