新产品编号:834223

Chemical Name: 2-[2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)quinolin-4-ylamino]ethanol
CAS No. 332181-97-2, 332180-41-3 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:Regioselective substitution of the 2-chloro group of 2,4-dichloroquinoline (I) with 1,2,3,4-tetrahydroisoquinoline (II) in refluxing toluene provides the 2-(tetrahydroisoquinolinyl)quinoline (III).Then,displacement of the remaining 4-chloro group by heating with ethanolamine (IV) furnishes the title compound