PTX-031553

Chemical Name: 5-Chloro-2-(4-chloro-3-nitrophenylsulfonamido)-N-(4-chlorophenyl)benzamide
CAS No. 136402-17-0
项目整合开发状态: Biological Testing
项目研究机构: PanTherix (Originator)
合成路线:Condensation of anthranilic acid (I) with 4-chloro-3-nitrobenzenesulfonyl chloride (II) in the presence of Na2CO3 affords sulfonamide (III).Electrophilic chlorination of (III) employing sulfuryl chloride in hot AcOH leads to (IV).After activation of acid (IV) as the corresponding acid chloride (V),coupling with 4-chloroaniline (VI) furnishes the target anthranilamide.