新产品编号:174529
Chemical Name: 2',3'-O-Diacetyl-5'-[N-[4-amino-2(Z)-butenyl]-N-methylamino]-5'-deoxyadenosine
CAS No. 183277-44-3
项目整合开发状态: Preclinical
项目研究机构: Pace University (Originator), Roswell Park Cancer Institute (Originator), Wake Forest University (Originator)
合成路线:The primary hydroxyl group of adenosine (I) is chlorinated by means of SOCl2 to afford chloride (II),which is then displaced by methylamine at 55 C in a pressure vessel to furnish amine (III).Subsequent alkylation of (III) with the allyl chloride (IV) in hot DMF provides (V).After esterification of diol (V) with acetic anhydride,the resultant diacetate (VI) is subjected to acid-catalyzed N-Boc group cleavage to furnish the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth,trypanosomal growth,and HIV-1 infectivity
文献作者:Marasco,C.J.; Kramer,D.L.; Miller,J.; Porter,C.W.; Bacchi,C.J.; Rattendi,D.; Kucera,L.; Iyer,N.; Bernacki,R.; Pera,P.; Sufrin,J.R.
参考来源:J Med Chem 2002,45(23),5112