RTI-4229-336, RTI-336
Chemical Name: (exo,exo)-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)isoxazol-5-yl]-8-azabicyclo[3.2.1]octane hydrochloride
CAS No. 204069-50-1, 236754-02-2 (free base)
项目整合开发状态: Preclinical
项目研究机构: Research Triangle Institute (Originator)
合成路线:Condensation of 3-beta-(4-chlorophenyl)-2-beta-(carbomethoxy)tropane (I) with the lithiated derivative of 4-methylacetophenone oxime (II) leads to the beta-keto oxime (III).Cyclizative dehydration of (III) upon heating in the presence of sulfuric acid provides the target isoxazole compound.
📌 参考资料/链接：
参考文献标题:Cocaine receptor binding ligands
文献作者:Kuhar,M.J.; Carroll,F.I.; Boja,J.W.; Lewin,A.H.; Abraham,P.(Research Triangle Institute)
参考来源:EP 0993301; JP 2001525795; US 6531483; WO 9807427
📄 详细内容
合成路线:Condensation of 3-beta-(4-chlorophenyl)-2-beta-(carbomethoxy)tropane (I) with the lithiated derivative of 4-methylacetophenone oxime (II) leads to the beta-keto oxime (III).Cyclizative dehydration of (III) upon heating in the presence of sulfuric acid provides the target isoxazole compound.
参考文献标题:Cocaine receptor binding ligands
文献作者:Abraham,P.; Kuhar,M.J.; Boja,J.W.; Lewin,A.H.; Carroll,F.I.(Research Triangle Institute)
参考来源:EP 1079833; JP 2002516278; US 6482837; WO 9961023
合成路线:Condensation of 3-beta-(4-chlorophenyl)-2-beta-(carbomethoxy)tropane (I) with the lithiated derivative of 4-methylacetophenone oxime (II) leads to the beta-keto oxime (III).Cyclizative dehydration of (III) upon heating in the presence of sulfuric acid provides the target isoxazole compound.
参考文献标题:Synthesis,monoamine transporter binding properties,and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes
文献作者:Carroll,F.Y.; Pawlush,N.; Kuhar,M.J.; Pollard,G.T.; Howard,J.L.
参考来源:J Med Chem 2004,47(2),296
产品链接: CAS No. 204069-50-1›› 产品链接: CAS No.236754-02-2››