新产品编号:742467
Chemical Name: Nitric acid 3-[2-(4-biphenylyl)-4-methylmorpholin-2-yloxy]propyl ester hydrobromide
CAS No. 283168-16-1 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Aristotle University of Thessaloniki (Originator), Elpen (Originator)
合成路线:Condensation of 4-bromoacetylbiphenyl (I) with N-methyl ethanolamine (II) leads to the 2-hydroxymorpholine (III).The acid-catalyzed reaction of the hemiketal (III) with 3-bromo-1-propanol (IV) gives the bromopropoxy morpholine (V),which is finally converted into the title nitrate ester by treatment with AgNO3 in acetonitrile.(1,2)
📌 参考资料/链接：
参考文献标题:Hypolipidemic and antioxidant morpholine derivs.
文献作者:Chrysselis,M.; Rekka,E.; Kourounakis,P.(Elpen Pharm.Co.)
参考来源:CA 2359476; EP 1140877; US 6693192; WO 0042030
📄 详细内容
合成路线:Condensation of 4-bromoacetylbiphenyl (I) with N-methyl ethanolamine (II) leads to the 2-hydroxymorpholine (III).The acid-catalyzed reaction of the hemiketal (III) with 3-bromo-1-propanol (IV) gives the bromopropoxy morpholine (V),which is finally converted into the title nitrate ester by treatment with AgNO3 in acetonitrile.(1,2)
参考文献标题:Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents
文献作者:Chrysselis,M.C.; Rekka,E.A.; Siskou,I.C.; Kourounakis,P.N.
参考来源:J Med Chem 2002,45(24),5406