项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

N-2733

Chemical Name: 1-[3-(3-Pyridinyl)-2(E)-propenoyl]-2-pyrrolidinone hydrochloride
CAS No. 141236-60-4 (free base), 132220-88-3 (undefined isomer, free base)
项目整合开发状态: Preclinical
项目研究机构: Nisshi...
参考文献标题:Pyrrolidinone derivs.
文献作者:Nagasaka,T.; Yamada,H.; Hamaguchi,F.(Nisshin Flour Milling Co.,Ltd.)
参考来源:JP 1990225458

新产品编号:517823

Chemical Name: 3'-Azido-5'-O-[4-bromophenoxy[1-(methoxycarbonyl)ethylamino]phosphoryl]-3'-deoxythymidine
CAS No. 220693-38-9
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Orig...
参考文献标题:AZT-5'-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent
文献作者:Jan,S.T.; Zhu,Z.; Tai,H.L.; Shih,M.J.; Venkatachalam,T.K.; Uckun,F.M.
参考来源:Antivir Chem Chemother 1999,10(1),47

VUF-K-8788

Chemical Name: 7-[3-[4-(2-Quinolinylmethyl)-1-piperazinyl]propoxy]-3,4-dihydro-2H-1,4-benzothiazin-3-one
CAS No. 219741-10-3
项目整合开发状态: Preclinical
项目研究机构: Kowa (Originator)
合成路线:The alkyla...
参考文献标题:Diamine derivs.and pharmaceutical containing the same
文献作者:Tohma,T.; Onogi,K.; Zang,M.; Timmerman,H.; Wada,Y.; Tamura,M.(Kowa Co.,Ltd.)
参考来源:EP 0957100; WO 9902520

NK-5807

Chemical Name: (-)-N-[4-(10-Acetamido-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridin-2-yl)-2(S)-(3,4-dichlorophenyl)butyl]-N-methylbenzamide maleate
CAS No. 219536-57-9 (free base), 219536-58-0 (fumar...
参考文献标题:Novel naphthyridine derivs.or salts thereof
文献作者:Honda,M.; Sato,Y.; Oka,H.; Iida,M.(Nippon Kayaku Co.,Ltd.)
参考来源:EP 0997462; JP 2000038386; US 6294547; WO 9900388

新产品编号:992423

Chemical Name: N-[4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]pyridine-2-carboxamide
CAS No. 86800-33-1
项目整合开发状态: Biological Testing
项目研究机构: Second Military Medical University (...
参考文献标题:Synthesis and platelet aggregation inhibitory activity of 6-(4'-substituted acylaminophenyl)-4,5-dihydro-3-(2H)-pyridazinones
文献作者:Liu,C.M.; et al.
参考来源:Acta Pharm Sin 1999,34(1),23

新产品编号:990841

Chemical Name: N-[4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]pyridine-4-carboxamide
CAS No. 86800-32-0
项目整合开发状态: Biological Testing
项目研究机构: Second Military Medical University (...
参考文献标题:Synthesis and platelet aggregation inhibitory activity of 6-(4'-substituted acylaminophenyl)-4,5-dihydro-3-(2H)-pyridazinones
文献作者:Liu,C.M.; et al.
参考来源:Acta Pharm Sin 1999,34(1),23

新产品编号:97011

Chemical Name: [5R-(5alpha,5abeta,8aalpha,9beta)]-9-(4-Amino-5-ethyl-4H-1,2,4-triazol-3-ylsulfanyl)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)...
参考文献标题:Synthesis and antitumor activities of 4beta-S-(5''-alkyl-4''-amino-1'',2'',4''-triazole-3''-yl)-4-deoxy-4'-O-demethyl-epipodophyllotoxin derivatives
文献作者:Chen,Y.Z.; Lu,K.K.
参考来源:Acta Pharm Sin 1999,34(1),63

新产品编号:98593

Chemical Name: [5R-(5alpha,5abeta,8aalpha,9beta)]-9-(4-Amino-5-propyl-4H-1,2,4-triazol-3-ylsulfanyl)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6...
参考文献标题:Synthesis and antitumor activities of 4beta-S-(5''-alkyl-4''-amino-1'',2'',4''-triazole-3''-yl)-4-deoxy-4'-O-demethyl-epipodophyllotoxin derivatives
文献作者:Chen,Y.Z.; Lu,K.K.
参考来源:Acta Pharm Sin 1999,34(1),63

新产品编号:76445

Chemical Name: 2,2-Dichloro-N-[2-[3-(1H-indol-3-yl)-2-quinolinylmethyl]phenyl]acetamide
CAS No. 159018-53-8
项目整合开发状态: Preclinical
项目研究机构: Indian Institute of Chemical Biology (Originator)
...
参考文献标题:Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis
文献作者:Chakrabarti,G.; Basu,A.; Manna,P.P.; Mahato,S.B.; Mandal,N.B.; Bandyopadhyay,S.
参考来源:J Antimicrob Chemother 1999,43(3),359

新产品编号:78027

Chemical Name: 2-Chloro-N-[2-[3-(1H-indol-3-yl)-2-quinolinylmethyl]phenyl]acetamide
CAS No. 159018-54-9
项目整合开发状态: Biological Testing
项目研究机构: Indian Institute of Chemical Biology (Originator)<...
参考文献标题:Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis
文献作者:Chakrabarti,G.; Basu,A.; Manna,P.P.; Mahato,S.B.; Mandal,N.B.; Bandyopadhyay,S.
参考来源:J Antimicrob Chemother 1999,43(3),359