项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:38477

Chemical Name: 1-[3,3-Dimethyl-5-[5-[3-(4-methylphenyl)propyl]thien-2-yl]pentyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
CAS No. 136572-76-4, 136573-13-2 (free base)
项目整合开发状态: Precl...
参考文献标题:Thiophene derivs.,process for their preparation and pharmaceutical compsns.containing them
文献作者:Wierzbicki,M.; Sauveur,F.; Bonnet,J.; Brisset,M.; Tordjman,C.(ADIR et Cie.)
参考来源:AU 9166901; EP 0429370; FR 2655043; JP 1991190872; US 5061704

新产品编号:456125

Chemical Name: 1-[1-(4-Fluorobenzyl)-5-phenyl-1H-1,2,4-triazol-3-ylmethyl]-4-(4-methoxyphenyl)piperazine
CAS No. 217966-61-5
项目整合开发状态: Biological Testing
项目研究机构: University of Athens (Origina...
参考文献标题:Synthesis,antifungal activity and antibacterial evaluation of some 3-piperazinylmethyl-5-aryl-1H-1,2,4-triazoles
文献作者:Chytiroglou-Lada,A.; Filippatos,E.C.; Papakonstantinou-Garoufalias,S.S.; Papadaki-Valiraki,A.E.; Todoulou,O.G.
参考来源:Arzneim-Forsch Drug Res 1998,48(10),1019

新产品编号:457707

Chemical Name: 1-[1-(4-Fluorobenzyl)-5-(4-methylphenyl)-1H-1,2,4-triazol-3-ylmethyl]-4-(4-methoxyphenyl)piperazine
CAS No. 217966-67-1
项目整合开发状态: Biological Testing
项目研究机构: University of Athen...
参考文献标题:Synthesis,antifungal activity and antibacterial evaluation of some 3-piperazinylmethyl-5-aryl-1H-1,2,4-triazoles
文献作者:Chytiroglou-Lada,A.; Filippatos,E.C.; Papakonstantinou-Garoufalias,S.S.; Papadaki-Valiraki,A.E.; Todoulou,O.G.
参考来源:Arzneim-Forsch Drug Res 1998,48(10),1019

LG-121071

Chemical Name: 6-Ethyl-4-(trifluoromethyl)-1,2,6,7,8,9-hexahydropyrido[3,2-g]quinolin-2-one
CAS No. 179897-70-2
项目整合开发状态: Preclinical
项目研究机构: Ligand (Originator)
合成路线:The Skraup reaction o...
参考文献标题:Steroid receptor modulator cpds.and methods
文献作者:Jones,T.K.; Goldman,M.E.; Pooley,C.L.F.; Winn,D.T.; Edwards,J.E.; West,S.J.; Tegley,C.M.; Zhi,L.; Hamann,L.G.; Farmer,L.J.; Davis,R.J.(Ligand Pharmaceuticals,Inc.)
参考来源:EP 0800519; JP 1998510840; US 5688808; US 5688810; US 5693646; US 5693647; US 5696127; US 5696130; US 5696133; WO 9619458

NSC-693569

Chemical Name: gamma-L-Glutamyl-L-[S-[N-(4-chlorophenyl)-N-hydroxycarbamoyl]]cysteinyl-glycine diethyl ester hydrochloride; S-[N-(4-chlorophenyl)-N-hydroxycarbamoyl]glutathione diethyl ester hydrochlo...
参考文献标题:Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth
文献作者:Creighton,D.J.; Hamilton,D.S.(University of Maryland)
参考来源:US 5616563; WO 9600061

新产品编号:514659

Chemical Name: 3'-Azido-3'-deoxythymidine 5'--[11-[[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetraazacyclotetradecane-1 pentanoate]
CAS No. 220481-73-2
项目整合开发状态: Bi...
参考文献标题:New bicyclam-AZT conjugates: Design,synthesis,anti-HIV evaluation,and their interaction with CXCR-4 coreceptor
文献作者:Dessolin,J.; Galea,P.; Vlieghe,P.; Chermann,J.-C.; Kraus,J.-L.
参考来源:J Med Chem 1999,42(2),229

R-146225

Chemical Name: (-)-2-[3,5-Dichloro-4-[1-(4-chlorophenyl)-1-(2-pyrimidinylsulfanyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS No. 219979-42-7
项目整合开发状态: Preclinical
项目研究机构: Janssen (Ori...
参考文献标题:IL-5 inhibiting 6-azauracil derivs.
文献作者:Freyne,E.J.E.; Lacrampe,J.F.A.; Boeckx,G.M.; Venet,M.G.(Janssen Pharmaceutica NV)
参考来源:EP 1000040; WO 9902505

新产品编号:421321

Chemical Name: N-[2-[N-[4-Chloro-2-cyano-3-(2-methylquinolin-8-yloxymethyl)phenyl]-N-methylamino]-2-oxoethyl]-3-methoxycinnamamide
CAS No. 213987-32-7
项目整合开发状态: Biological Testing
项目研究机构: Ave...
参考文献标题:Fused N-heterocyclic cpds.substd.with benzyloxy,process for their preparation and their use as bradykinin receptor antagonists
文献作者:Heitsch,H.; Wirth,K.; Sch鰈kens,B.; Wagner,A.(Aventis SA)
参考来源:DE 19712960; EP 0867432; JP 1998279563

新产品编号:267867

Chemical Name: N-[1(S)-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-yl)ethyl]-3-phenyl-2(E)-propenamide
CAS No. 194352-21-1
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)<...
参考文献标题:Thienoxazinone derivs.useful as antiviral agents
文献作者:Jarvest,R.L.; Jennings,L.J.A.; Pinto,I.L.(SmithKline Beecham plc)
参考来源:WO 9727200

新产品编号:437141

Chemical Name: 2-Acetyl-4,8-dihydrobenzo[12,-b:5,4-b']dithiophene-4,8-dione
CAS No. 215371-62-3
项目整合开发状态: Biological Testing
项目研究机构: China Medical College (Originator), National Institutes of...
参考文献标题:Synthesis and cytotoxicity of 2-acetyl-4,8-dihydrobenzodithiophene-4,8-dione derivatives
文献作者:Chao,Y.-H.; Kuo,S.-C.; Wu,C.-H.; Lee,C.-Y.; Mauger,A.; Sun,I.-C.; Morris-Natschke,S.L.; Lee,K.-H.
参考来源:J Med Chem 1998,41(23),4658