新产品编号:456125

Chemical Name: 1-[1-(4-Fluorobenzyl)-5-phenyl-1H-1,2,4-triazol-3-ylmethyl]-4-(4-methoxyphenyl)piperazine
CAS No. 217966-61-5
项目整合开发状态: Biological Testing
项目研究机构: University of Athens (Originator)
合成路线:The condensation of 1-(4-methoxyphenyl)piperazine (I) with ethyl chloroacetate (II) gives the expected condensation product (III),which by treatment with hydrazine in converted into the corresponding hydrazide (IV).The cyclization of (IV) with benzimidate (V) by heating at 180 C affords the triazole (VI),which is finally condensed with 4-fluorobenzyl chloride (VII) by means of NaH in DMF.

合成路线:The condensation of 1-(4-methoxyphenyl)piperazine (I) with ethyl chloroacetate (II) gives the expected condensation product (III),which by treatment with hydrazine in converted into the corresponding hydrazide (IV).The cyclization of (IV) with 4-methylbenzimidate (V) by heating at 180 C affords the triazole (VI),which is finally condensed with 4-fluorobenzyl chloride (VII) by means of NaH in DMF.