项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

新产品编号:255211

Chemical Name: 3-(Diphenylmethylidene)-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-ylmethyl]-2,5-pyrrolidinedione dihydrochloride hydrate
CAS No. 193287-08-0 (anhydrous)
项目整合开发状态: Biological Tes...
参考文献标题:New imidapiperazine derivs.
文献作者:K.Rovat,T.; Oesanz Mu駉,L.M.; Fern醤dez Velando,E.; L髉ez Rodr韌uez,M.L.; Rosado Samitier,M.L.; Morcillo Ortega,M.J.(Universidad Complutense de Madrid)
参考来源:ES 2094690

新产品编号:342221

Chemical Name: 2(R)-[N-Benzyl-N-[[R(P)]-(methyl)phenylphosphoryl]amino]-N-hydroxy-4-methylpentanehydroxamic acid; N2-Benzyl-N2-[[R(P)]-methyl(phenyl)phosphoryl]-N1-hydroxy-D-leucinamide
CAS No. 204...
参考文献标题:Phosphinic acid amides as matrix metalloprotease inhibitors
文献作者:Taiwo,Y.O.; Pikul,S.; De,B.; McDow-Dunham,K.L.(The Procter & Gamble Co.)
参考来源:US 5830915; WO 9808853

新产品编号:978185

Chemical Name: 2-(2,4-Dihydroxyphenyl)-4,5-dihydrothiazole-4(S)-carboxylic acid
CAS No. 57980-69-5 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: University of Florida (Originator)
合成路线:...
参考文献标题:Thiazoline acid derivs.
文献作者:Bergeron,R.J.Jr.(University of Florida)
参考来源:WO 0012493

PNU-173995

Chemical Name: N-[3-[3-Fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxooxazolidin-5(S)-ylmethyl]thioacetamide
CAS No. 216868-84-7
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator) 参考文献标题:Oxazolidinone antibacterial agents having a thiocarbonyl functionality
文献作者:Hester,J.B.Jr.; Perricone,S.C.; Nidy,E.G.; Poel,T.-J.(Pharmacia Corp.)
参考来源:EP 0984947; JP 2002501530; US 6218413; WO 9854161

K-10085

Chemical Name: N-[6-Methyl-2,4-bis(methylsulfanyl)-3-pyridinyl]-2-[4-[2-(oxazolo[4,5-b]pyridin-2-ylsulfanyl)ethyl]-1-piperazinyl]acetamide
CAS No. 217094-22-9
项目整合开发状态: Preclinical
项目研究机构: Ko...
参考文献标题:Novel cyclic diamine cpds.and medicine containing the same
文献作者:Kawamine,K.; Miura,T.; Shibuya,K.; Ozaki,C.; Sato,Y.; Edano,T.; Hirata,M.(Kowa Co.,Ltd.)
参考来源:EP 0987254; WO 9854153

UK-321130

Chemical Name: (+)-5-[5-[4-[1(R)-[(2S,5R)-4-Allyl-2,5-dimethylpiperazin-1-yl]-1-(3-hydroxyphenyl)methyl]phenyl]-2H-tetrazol-2-yl]pentanoic acid
CAS No. 216531-42-9
项目整合开发状态: Preclinical
项目研究机...
参考文献标题:Anti-inflammatory piperazinyl-benzyl-tetrazole derivs.and intermediates thereof
文献作者:Maw,G.N.(Pfizer Inc.)
参考来源:EP 0983251; JP 2000513024; WO 9852929

91/146

Chemical Name: 6-(4-Bromophenyl)-4-(methylsulfanyl)-2-oxo-2H-pyran-3-carbonitrile
CAS No. 61380-87-8
项目整合开发状态: Preclinical
项目研究机构: Central Drug Research Institute (Originator)
合成路线:Title p...
参考文献标题:Syntheses of 2-pyrone derivatives
文献作者:Tominaga,Y.; et al.
参考来源:Heterocycles 1976,4(9),1493

SO-730

Chemical Name: 5'-O-[(O-Benzyl-L-alanino)(phenoxy)phosphoryl]-3'-deoxy-2',3'-didehydrothymidine
CAS No. 178469-24-4
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute for Medical Research (O...
参考文献标题:Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
文献作者:Balzarini,J.; De Clercq,E.; Sheeka,H.M.; Cahard,D.; McGuigan,C.
参考来源:Bioorg Med Chem Lett 1996,6(10),1183

BM-212

Chemical Name: 1-[1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-ylmethyl]-4-methylpiperazine
CAS No. 146204-42-4
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi "La Sapienza" (Origi...
参考文献标题:Studies on anti-Candida agents with a pyrrole moiety.Synthesis and microbiological activity of some 3-aminomethyl-1,5-diaryl-2-methyl-pyrrole derivatives
文献作者:Retico,A.; Cerreto,F.; Scalzo,M.; Villa,A.
参考来源:Eur J Med Chem 1992,27(7),701

新产品编号:40059

Chemical Name: 1-[3,3-Dimethyl-5-[5-[2-(4-methylphenyl)ethyl]thien-2-yl]pentyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
CAS No. 136572-80-0, 136573-15-4 (free base)
项目整合开发状态: Precli...
参考文献标题:Thiophene derivs.,process for their preparation and pharmaceutical compsns.containing them
文献作者:Wierzbicki,M.; Sauveur,F.; Bonnet,J.; Brisset,M.; Tordjman,C.(ADIR et Cie.)
参考来源:AU 9166901; EP 0429370; FR 2655043; JP 1991190872; US 5061704