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Chemical Name: 6-(4-Bromophenyl)-4-(methylsulfanyl)-2-oxo-2H-pyran-3-carbonitrile
CAS No. 61380-87-8
项目整合开发状态: Preclinical
项目研究机构: Central Drug Research Institute (Originator)
合成路线:Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.
📌 参考资料/链接：
参考文献标题:Syntheses of 2-pyrone derivatives
文献作者:Tominaga,Y.; et al.
参考来源:Heterocycles 1976,4(9),1493
📄 详细内容
合成路线:Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.
参考文献标题:Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles
文献作者:Parmar,V.S.; et al.
参考来源:Indian J Chem 1997,36B(10),872
合成路线:Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.
参考文献标题:Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate
文献作者:Ram,V.J.; et al.
参考来源:Indian J Chem 1993,32B(9),924
合成路线:Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.
参考文献标题:Synthesis and reactions of 6-aryl- and 6-styryl-3-cyano-4-methylthio-2H-pyran-2-ones
文献作者:Tominaga,Y.; et al.
参考来源:Chem Pharm Bull 1984,32(9),3384