新产品编号:978185
Chemical Name: 2-(2,4-Dihydroxyphenyl)-4,5-dihydrothiazole-4(S)-carboxylic acid
CAS No. 57980-69-5 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: University of Florida (Originator)
合成路线:Nitrile (II) was prepared by reaction of 2,4-dihydroxybenzaldehyde (I) with nitroethane and NaOAc in boiling AcOH.Subsequent condensation with D-cysteine (III) in the presence of phosphate buffer at pH 5.95 in MeOH provided the title thiazolidine.
📌 参考资料/链接：
参考文献标题:Thiazoline acid derivs.
文献作者:Bergeron,R.J.Jr.(University of Florida)
参考来源:WO 0012493
📄 详细内容
合成路线:Nitrile (II) was prepared by reaction of 2,4-dihydroxybenzaldehyde (I) with nitroethane and NaOAc in boiling AcOH.Subsequent condensation with D-cysteine (III) in the presence of phosphate buffer at pH 5.95 in MeOH provided the title thiazolidine.
参考文献标题:Desazadesmethyldesferrithiocin analogues as orally effective iron chelators
文献作者:Bergeron,R.J.; Wiegand,J.; Weimar,W.R.; Vinson,J.R.; Bussenius,J.; Yao,G.W.; McManis,J.S.
参考来源:J Med Chem 1999,42(1),95